SCHEMBL331398

SCHEMBL331398

Sc1cc(Cl)cc(S)c1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.53
TSHR P16473 8/20 0.47
HSD17B10 Q99714 7/20 0.41
HPGD P15428 6/20 0.41
AHR P35869 3/20 0.41
CYP3A4 P08684 6/20 0.40
RECQL P46063 2/20 0.40
TP53 P04637 2/20 0.35
IDO1 P14902 2/20 0.35
CASP1 P29466 2/20 0.33
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
CES1 P23141 1/20 0.31
DNMT1 P26358 1/20 0.31
MAPK1 P28482 2/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
SLC22A2 O15244 1/20 0.31
SLC22A1 O15245 1/20 0.31
NR1I2 O75469 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9194533 0.91 ALDH1A1 (0.61) ALDH1A1TSHRHSD17B10HPGDAHR
SCHEMBL4304036 0.78 ALDH1A1 (0.45) ALDH1A1TSHRHSD17B10HPGDAHR
SCHEMBL19872483 0.76 PDK2 (0.38) ALDH1A1TSHRHSD17B10HPGDCYP3A4
SCHEMBL17431299 0.74 ERN1 (0.40) ALDH1A1HPGDCYP3A4MAPK1KDM4E
SCHEMBL8851058 0.74 HSD17B10 (0.65) ALDH1A1TSHRHSD17B10HPGDCYP3A4
SCHEMBL8602957 0.74 ALDH1A1 (0.43) ALDH1A1TSHRHSD17B10HPGDAHR
SCHEMBL48413 0.73 CYP3A4 (0.59) ALDH1A1TSHRHSD17B10HPGDAHR
SCHEMBL10826043 0.73 TSHR (0.50) ALDH1A1TSHRHSD17B10HPGDCYP3A4
SCHEMBL1392834 0.71 ALDH1A1 (0.53) ALDH1A1TSHRHSD17B10HPGDAHR
SCHEMBL4229727 0.71 CYP3A4 (0.56) ALDH1A1TSHRHSD17B10HPGDAHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 281 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3483219-B1 TRANSPARENT PLASTIC SUBSTRATE AND PLASTIC LENS HOYA LENS THAILAND LTD (TH) 2024-08-14 EP disclosed
US-12054568-B2 Optical material composition and optical material TOKUYAMA CORPORATION (JP) 2024-08-06 US disclosed
EP-3643735-B1 PHOTOCHROMIC POLYROTAXANE COMPOUND, AND CURABLE COMPOSITION CONTAINING SAID PHOTOCHROMIC POLYROTAXANE COMPOUND TOKUYAMA CORP (JP) 2024-07-31 EP disclosed
CN-110869355-B Benzopyran compound, curable composition containing the compound, and optical article containing cured product formed from the curable composition 株式会社德山 2023-11-14 CN disclosed
CN-112424260-B Photochromic compound and curable composition containing the same 株式会社德山 2023-10-13 CN disclosed
US-11767467-B2 Photochromic compound and curable composition containing said photochromic compound TOKUYAMA CORPORATION (JP) 2023-09-26 US disclosed
CN-116438214-A Sealing material for organic EL display element, cured product thereof, and organic EL display device 三井化学株式会社 2023-07-14 CN disclosed
EP-3345954-B1 POLYROTAXANE, PRODUCTION METHOD THEREFOR, AND OPTICAL COMPOSITION CONTAINING SAID POLYROTAXANE TOKUYAMA CORP (JP) 2023-07-05 EP disclosed
CN-113045885-B Transparent plastic substrate and plastic lens 豪雅镜片泰国有限公司 2023-03-21 CN disclosed
EP-3653615-B1 CHROMENE COMPOUND, CURABLE COMPOSITION COMPRISING SAME, AND OPTICAL ARTICLE COMPRISING CURED PRODUCT FORMED OF CURABLE COMPOSITION TOKUYAMA CORP (JP) 2023-03-01 EP disclosed
EP-0374258-A1 HIGH REFRACTIVE INDEX LENS AND METHOD FOR ITS PRODUCTION MITSUI CHEMICALS, INC. (JP) 1990-06-27 EP disclosed
EP-0351073-A2 Lens comprising a resin having a large refractive index and process for preparing the lens MITSUI TOATSU CHEMICALS, Inc. (JP) 1990-01-17 EP disclosed
EP-0330363-A2 Highly-refractive plastic lens and process for making the lens MITSUI TOATSU CHEMICALS, Inc. (JP) 1989-08-30 EP disclosed
EP-0329387-A2 Plastic lens, and method for its preparation MITSUI TOATSU CHEMICALS, Inc. (JP) 1989-08-23 EP disclosed
US-4737574-A Poly(amide-thioether) containing thermoset polymeric composition from reaction of bisoxazoline with polythiol in the presence of certain cationic catalyst ASHLAND OIL, INC. (US) 1988-04-12 US disclosed
US-4696992-A Thiol carbamates as latent accelerators for curing epoxy resins ASHLAND OIL, INC. (US) 1987-09-29 US disclosed
EP-0050261-B1 MOULDING MASSES STABILIZED AGAINST THERMOLYSIS WITH A LOW MONOMER CONTENT BAYER AG (DE) 1985-08-14 EP disclosed
EP-0050261-A1 Moulding masses stabilized against thermolysis with a low monomer content BAYER AG (DE) 1982-04-28 EP disclosed
US-3979369-A DIENE POLYMER MONSANTO COMPANY (US) 1976-09-07 US disclosed
US-3974163-A VULCANIZATION INHIBITOR MONSANTO COMPANY (US) 1976-08-10 US disclosed