Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 10/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | MC3R | P41968 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL33142 | 0.92 | EGFR (0.50) | EGFRERBB4ERBB2JAK3GAK | |
| SCHEMBL4414699 | 0.76 | MAPT (0.41) | — | |
| SCHEMBL14470651 | 0.76 | EGFR (0.52) | EGFRERBB4ERBB2JAK3GAK | |
| SCHEMBL24784988 | 0.74 | EGFR (0.59) | EGFRERBB4ERBB2JAK3GAK | |
| SCHEMBL13818731 | 0.74 | EGFR (0.45) | EGFRERBB4ERBB2JAK3GAK | |
| SCHEMBL14605834 | 0.73 | EGFR (0.38) | EGFRERBB2 | |
| SCHEMBL14147701 | 0.73 | KDR (0.40) | — | |
| SCHEMBL19779461 | 0.70 | EGFR (0.59) | EGFRERBB4ERBB2JAK3GAK | |
| SCHEMBL13267377 | 0.69 | EGFR (0.63) | EGFRERBB4ERBB2JAK3GAK | |
| SCHEMBL12262261 | 0.68 | EGFR (0.66) | EGFRERBB4ERBB2JAK3GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1746999-B1 | 4-PHENYLAMINO-QUINAZOLIN-6-YL-AMIDES | WARNER LAMBERT CO (US) | 2011-11-16 | — | — | EP | disclosed |