Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 9/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13818731 | 0.78 | EGFR (0.45) | MAPT | |
| SCHEMBL33141 | 0.76 | EGFR (0.48) | — | |
| SCHEMBL14605834 | 0.76 | EGFR (0.38) | MAPTHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12838368 | 0.74 | MEN1 (0.33) | MAPTHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14147701 | 0.71 | KDR (0.40) | TSHRKDM4ECSF1R | |
| SCHEMBL16199864 | 0.64 | MAPT (0.43) | MAPTHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11884293 | 0.64 | KMT2A (0.59) | MAPTHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12838303 | 0.62 | EGFR (0.40) | MAPTHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4730870 | 0.62 | MAPT (0.67) | MAPTHTTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4730873 | 0.62 | MAPT (0.67) | MAPTHTTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492536-B1 | 4-(N-PHENYLAMINO)-QUINAZOLINES / QUINOLINES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2012-05-09 | — | — | EP | disclosed |