Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.84 |
| ▸ | POLB | P06746 | 1/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | XBP1 | P17861 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.53 |
| ▸ | CFTR | P13569 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20988947 | 0.92 | KDM4E (1.00) | KDM4EALDH1A1POLBKMT2ANPSR1 | |
| SCHEMBL3312492 | 0.89 | KDM4E (0.84) | KDM4EALDH1A1POLBKMT2ANPSR1 | |
| SCHEMBL3313022 | 0.88 | KDM4E (0.86) | KDM4EALDH1A1POLBKMT2ANPSR1 | |
| SCHEMBL3312894 | 0.85 | PKM (0.66) | KDM4EALDH1A1POLBKMT2APKM | |
| SCHEMBL3312063 | 0.83 | KDM4E (0.83) | KDM4EALDH1A1POLBKMT2ANPSR1 | |
| SCHEMBL3313107 | 0.83 | KMT2A (0.62) | KDM4EALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL3319431 | 0.83 | KMT2A (0.61) | KDM4EALDH1A1POLBKMT2AMEN1 | |
| SCHEMBL3312780 | 0.80 | KDM4E (0.56) | KDM4EALDH1A1POLBKMT2ANPSR1 | |
| SCHEMBL20989169 | 0.80 | KDM4E (0.69) | KDM4EALDH1A1POLBKMT2ANPSR1 | |
| SCHEMBL14133902 | 0.79 | KDM4E (0.70) | KDM4EALDH1A1POLBKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | THE TRUSTEES OF THE STEVENS INSTITUTE OF TECHNOLOG (US) | 2019-05-09 | — | — | US | disclosed |
| US-20100105729-A1 | ARYL-SUBSTITUTED HETEROCYCLIC PDE4 INHIBITORS AS ANTI-INFLAMMATORY AGENTS | KALYPSYS, INC. (US) | 2010-04-29 | — | — | US | disclosed |
| US-20100105729-A1 | ARYL-SUBSTITUTED HETEROCYCLIC PDE4 INHIBITORS AS ANTI-INFLAMMATORY AGENTS | KALYPSYS, INC. (US) | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190134056-A1 | K-RAS MUTATIONS AND ANTAGONISTS | KRAS, NRAS, HRAS | KDM4E 4410/4885ALDH1A1 4716/4885POLB 610/4885 |
| US-20100105729-A1 | ARYL-SUBSTITUTED HETEROCYCLIC PDE4 INHIBITORS AS ANTI-INFLAMMATORY AGENTS | PDE4A, PDE4B, PDE4C | KDM4E 332/4885ALDH1A1 576/4885POLB 2448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.