Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 11/20 | 0.84 |
| ▸ | CDK2 | P24941 | 7/20 | 0.83 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.66 |
| ▸ | INSR | P06213 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345579 | 0.92 | IGF1R (0.84) | IGF1RCDK2ALKINSR | |
| SCHEMBL2350977 | 0.91 | IGF1R (1.00) | IGF1RCDK2ALK | |
| SCHEMBL2351237 | 0.91 | IGF1R (1.00) | IGF1RCDK2ALKINSR | |
| SCHEMBL2351194 | 0.90 | IGF1R (0.82) | IGF1RCDK2ALKINSR | |
| SCHEMBL3311650 | 0.88 | IGF1R (0.84) | IGF1RCDK2ALK | |
| SCHEMBL13362109 | 0.84 | IGF1R (0.75) | IGF1RCDK2ALK | |
| SCHEMBL3314030 | 0.83 | IGF1R (0.85) | IGF1RCDK2ALKINSR | |
| SCHEMBL2345721 | 0.83 | IGF1R (0.85) | IGF1RCDK2ALKINSR | |
| SCHEMBL3312532 | 0.82 | IGF1R (1.00) | IGF1RCDK2INSR | |
| SCHEMBL2346279 | 0.82 | IGF1R (0.89) | IGF1RCDK2ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | claimed |
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | ASTRAZENECA AB | 2010-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105655-A1 | NOVEL COMPOUNDS 515 | TYMS, ABCG2, UMPS | IGF1R 4384/4885CDK2 64/4885ALK 3801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.