Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 15/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 15/20 | 0.56 |
| ▸ | IKBKB | O14920 | 3/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3315032 | 0.93 | SLC6A2 (0.65) | SLC6A2SLC6A4SLC6A3IKBKBCHUK | |
| SCHEMBL3314644 | 0.90 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3IKBKBPRKCZ | |
| SCHEMBL3315001 | 0.78 | IKBKB (0.49) | SLC6A2SLC6A4SLC6A3IKBKBPRKCZ | |
| Hydrochloric Acid SCHEMBL23360072 | 0.77 | IKBKB (0.48) | SLC6A2SLC6A4SLC6A3IKBKBPRKCZ | |
| Hydrochloric Acid SCHEMBL29862799 | 0.77 | IKBKB (0.48) | SLC6A2SLC6A4SLC6A3IKBKBPRKCZ | |
| Hydrochloric Acid SCHEMBL29862933 | 0.72 | IKBKB (0.51) | SLC6A2SLC6A4SLC6A3IKBKBPRKCZ | |
| Hydrochloric Acid SCHEMBL23360215 | 0.72 | IKBKB (0.51) | SLC6A2SLC6A4SLC6A3IKBKBPRKCZ | |
| SCHEMBL312413 | 0.71 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3ROCK1 | |
| SCHEMBL5649555 | 0.70 | SLC6A4 (0.50) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3314997 | 0.69 | IKBKB (0.48) | IKBKBPRKCZROCK1CHUKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8748614-B2 | Substituted isoquinoline and isoquinolinone derivatives | SANOFI (FR) | 2014-06-10 | — | — | US | disclosed |
| US-8748614-B2 | Substituted isoquinoline and isoquinolinone derivatives | SANOFI (FR) | 2014-06-10 | — | — | US | disclosed |
| US-8748614-B2 | Substituted isoquinoline and isoquinolinone derivatives | SANOFI (FR) | 2014-06-10 | — | — | US | disclosed |
| US-20100105650-A1 | Substituted isoquinoline and isoquinolinone derivatives | SANOFI-AVENTIS (FR) | 2010-04-29 | — | — | US | disclosed |
| US-20100105650-A1 | Substituted isoquinoline and isoquinolinone derivatives | SANOFI-AVENTIS (FR) | 2010-04-29 | — | — | US | disclosed |
| US-20100105650-A1 | Substituted isoquinoline and isoquinolinone derivatives | SANOFI-AVENTIS (FR) | 2010-04-29 | — | — | US | disclosed |
| EP-2114920-A1 | SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008077552-A1 | SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105650-A1 | Substituted isoquinoline and isoquinolinone derivatives | MYLK2, MYLK, MYLK3 | SLC6A2 2757/4885SLC6A4 3622/4885SLC6A3 3680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.