Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314095 | 0.90 | MAPK11 (0.57) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL241982 | 0.88 | HDAC1 (0.68) | MAPK11MAPK14HDAC1HDAC8HDAC6 | |
| SCHEMBL6248871 | 0.86 | ALDH1A1 (0.88) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL3314064 | 0.83 | MAPK14 (0.61) | MEN1KMT2AMAPK11MAPK14 | |
| SCHEMBL3314897 | 0.81 | ALDH1A1 (0.67) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL5713568 | 0.80 | ALDH1A1 (0.78) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL8612483 | 0.79 | EPHX1 (0.77) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL14906958 | 0.79 | ALDH1A1 (0.74) | NPC1RAB9AALDH1A1MAPTMEN1 | |
| SCHEMBL12676759 | 0.79 | MAPK11 (0.65) | MAPK11MAPK14 | |
| SCHEMBL10090842 | 0.78 | MAPK11 (0.57) | MAPK11MAPK14HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652044-B2 | P-38 inhibitors | NOVARTIS A.G. (CH) | 2010-01-26 | — | — | US | disclosed |
| US-20100004298-A1 | P-38 INHIBITORS | DONG QING | 2010-01-07 | — | — | US | disclosed |
| EP-1635824-B1 | 5-MEMBERED HETEROCYCLE-BASED P-38 INHIBITORS | NOVARTIS AG (CH) | 2009-08-19 | — | — | EP | disclosed |
| US-20040254236-A1 | P-38 inhibitors | NOVARTIS AG (CH) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004298-A1 | P-38 INHIBITORS | MAPK8, MAPK1, MAP3K8 | NPC1 975/4885RAB9A 1215/4885ALDH1A1 3347/4885 |
| US-20040254236-A1 | P-38 inhibitors | MAPK8, MAP3K8, MAPK1 | NPC1 1059/4885RAB9A 1402/4885ALDH1A1 3687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.