Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.78 |
| ▸ | HPGD | P15428 | 4/20 | 0.78 |
| ▸ | CASP1 | P29466 | 3/20 | 0.78 |
| ▸ | CASP7 | P55210 | 3/20 | 0.78 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.75 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3329684 | 0.86 | HSD17B10 (0.69) | ALDH1A1HSD17B10HPGDCASP1CASP7 | |
| SCHEMBL3330146 | 0.85 | ALDH1A1 (0.68) | ALDH1A1HSD17B10HPGDCASP1CASP7 | |
| SCHEMBL3320927 | 0.85 | KDM4E (0.82) | ALDH1A1HSD17B10HPGDCASP1CASP7 | |
| SCHEMBL3325346 | 0.81 | KDM4E (0.66) | ALDH1A1HSD17B10HPGDCASP1CASP7 | |
| SCHEMBL3324986 | 0.80 | KDM4E (0.71) | ALDH1A1HSD17B10HPGDCASP1CASP7 | |
| SCHEMBL13333270 | 0.80 | ALDH1A1 (0.70) | ALDH1A1HSD17B10HPGDCASP1CASP7 | |
| SCHEMBL3324606 | 0.80 | KDM4E (0.82) | ALDH1A1HSD17B10HPGDCASP1CASP7 | |
| SCHEMBL3329695 | 0.80 | ALDH1A1 (0.79) | ALDH1A1HSD17B10HPGDCASP1CASP7 | |
| SCHEMBL12135798 | 0.79 | KDM4E (1.00) | ALDH1A1HSD17B10HPGDCASP1CASP7 | |
| SCHEMBL3320322 | 0.79 | KDM4E (0.64) | ALDH1A1HSD17B10HPGDCASP1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | APP, MAPT, PSEN1 | ALDH1A1 2615/4885HSD17B10 1530/4885HPGD 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.