Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 1/20 | 0.74 |
| ▸ | LTA4H | P09960 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Anisole SCHEMBL29149580 | 0.95 | CA4 (0.74) | CA4LTA4HTSHRCA12CA1 | |
| Anisole SCHEMBL28813915 | 0.86 | CA4 (1.00) | CA4LTA4HTSHRCA12CA1 | |
| Anisole SCHEMBL1205 | 0.86 | — | — | |
| Anisole SCHEMBL2493788 | 0.86 | CA4 (1.00) | CA4LTA4HTSHRCA12CA1 | |
| Anisole SCHEMBL20328417 | 0.86 | — | — | |
| Anisole SCHEMBL8472521 | 0.86 | CA4 (1.00) | CA4LTA4HTSHRCA12CA1 | |
| Anisole SCHEMBL10721106 | 0.86 | CA4 (1.00) | CA4LTA4HTSHRCA12CA1 | |
| Anisole SCHEMBL30601749 | 0.86 | — | — | |
| Chlorobenzene SCHEMBL16876911 | 0.84 | CA4 (0.52) | CA4LTA4HTSHRCA12CA1 | |
| Anisole SCHEMBL29149574 | 0.84 | CA4 (0.74) | CA4LTA4HTSHRCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240150317-A1 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | GENZYME CORPORATION (US) | 2024-05-09 | — | — | US | disclosed |
| CN-116356362-A | Method for high-selectivity electrocatalytic simple aromatic oxidation through Fe-N-C catalytic electrode | 南京工业大学 | 2023-06-30 | — | — | CN | disclosed |
| WO-2023092044-A2 | PHENETHYLAMINE COMPOUNDS SALTS, POLYMORPHIC FORMS AND METHODS OF USE THEREOF | TERRAN BIOSCIENCES, INC. (US) | 2023-05-25 | — | — | WO | disclosed |
| US-20220033377-A1 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | GENZYME CORPORATION (US) | 2022-02-03 | — | — | US | disclosed |
| US-20190263782-A1 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | GENZYME CORPORATION (US) | 2019-08-29 | — | — | US | disclosed |
| US-10344015-B2 | Chemical process for the synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | GENZYME CORPORATION (US) | 2019-07-09 | — | — | US | disclosed |
| US-20180118716-A1 | Chemical Process | GENZYME CORPORATION (US) | 2018-05-03 | — | — | US | disclosed |
| US-9815816-B2 | Chemical process for the synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | GENZYME CORPORATION (US) | 2017-11-14 | — | — | US | disclosed |
| US-20160185754-A1 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | ASTRAZENECA AB (SE) | 2016-06-30 | — | — | US | disclosed |
| US-20140378684-A1 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | ASTRAZENECA AB (SE) | 2014-12-25 | — | — | US | disclosed |
| US-8163926-B2 | Process for the synthesis of piperidinyl sulphonate esters | ASTRAZENECA AB (SE) | 2012-04-24 | — | — | US | disclosed |
| US-20120095229-A1 | CHEMICAL PROCESS | GENZYME CORPORATION | 2012-04-19 | — | — | US | disclosed |
| US-8097876-B2 | Charge injection and transport layers | PLEXTRONICS, INC. (US) | 2012-01-17 | — | — | US | disclosed |
| EP-2053048-B1 | Chemical in situ sulphonating process | ASTRAZENECA AB (SE) | 2010-09-15 | — | — | EP | disclosed |
| US-20100109000-A1 | CHARGE INJECTION AND TRANSPORT LAYERS | PLEXTRONICS, INC. | 2010-05-06 | — | — | US | disclosed |
| EP-1943240-B1 | CHEMICAL PROCESS | ASTRAZENECA AB (SE) | 2009-11-11 | — | — | EP | disclosed |
| US-20090203905-A1 | CHEMICAL PROCESS | GENZYME CORPORATION | 2009-08-13 | — | — | US | disclosed |
| EP-2053048-A1 | Chemical in situ sulphonating process | AstraZeneca AB (SE) | 2009-04-29 | — | — | EP | disclosed |
| EP-1943240-A2 | CHEMICAL PROCESS | Astra Zeneca AB (SE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007036713-A2 | CHEMICAL PROCESS | ASTRAZENECA AB (SE) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378684-A1 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | CYP3A4, CYP3A7, CYP4B1 | CA4 239/4885LTA4H 2358/4885TSHR 3980/4885 |
| US-20220033377-A1 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | CYP3A4, CYP3A7, CYP4B1 | CA4 239/4885LTA4H 2358/4885TSHR 3980/4885 |
| US-20090203905-A1 | CHEMICAL PROCESS | CYP3A4, CYP3A5, CYP3A7 | CA4 217/4885LTA4H 2280/4885TSHR 3902/4885 |
| US-20240150317-A1 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | CYP3A4, CYP3A7, CYP4B1 | CA4 239/4885LTA4H 2358/4885TSHR 3980/4885 |
| US-20160185754-A1 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | CYP3A4, CYP3A7, CYP4B1 | CA4 239/4885LTA4H 2358/4885TSHR 3980/4885 |
| US-20190263782-A1 | Chemical Process for the Synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | CYP3A4, CYP3A7, CYP4B1 | CA4 239/4885LTA4H 2358/4885TSHR 3980/4885 |
| US-10344015-B2 | Chemical process for the synthesis of 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline | CYP3A4, CYP3A7, CYP4B1 | CA4 215/4885LTA4H 2185/4885TSHR 4036/4885 |
| US-20120095229-A1 | CHEMICAL PROCESS | CYP3A4, CYP3A5, CYP3A7 | CA4 217/4885LTA4H 2280/4885TSHR 3902/4885 |
| US-20180118716-A1 | Chemical Process | CYP3A4, CYP3A5, CYP3A7 | CA4 217/4885LTA4H 2280/4885TSHR 3902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.