Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323352 | 1.00 | TSHR (0.39) | TSHRWDR5ROCK2ROCK1PPARG | |
| SCHEMBL14110684 | 0.92 | PPARG (0.36) | WDR5PPARGPPARASMN1; SMN2NPC1 | |
| SCHEMBL14110687 | 0.92 | PPARG (0.36) | WDR5PPARGPPARASMN1; SMN2NPC1 | |
| SCHEMBL3326135 | 0.84 | TSHR (0.42) | TSHRWDR5ROCK2ROCK1PPARG | |
| SCHEMBL3326140 | 0.84 | TSHR (0.42) | TSHRWDR5ROCK2ROCK1PPARG | |
| SCHEMBL3324966 | 0.84 | TSHR (0.41) | TSHRWDR5ROCK2ROCK1PPARG | |
| SCHEMBL3324965 | 0.84 | TSHR (0.41) | TSHRWDR5ROCK2ROCK1PPARG | |
| SCHEMBL3322588 | 0.82 | TSHR (0.40) | TSHRWDR5ROCK2ROCK1PPARG | |
| SCHEMBL3322589 | 0.82 | TSHR (0.40) | TSHRWDR5ROCK2ROCK1PPARG | |
| SCHEMBL3323523 | 0.78 | TSHR (0.49) | TSHRWDR5ROCK2ROCK1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9743667-B2 | Substituted benzene fungicides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2017-08-29 | — | — | US | claimed |
| US-20150335023-A1 | SUBSTITUTED BENZENE FUNGICIDES | FMC CORPORATION | 2015-11-26 | — | — | US | claimed |
| US-20140323436-A1 | SUBSTITUTED BENZENE FUNGICIDES | FMC CORPORATION | 2014-10-30 | — | — | US | claimed |
| EP-2129225-B1 | SUBSTITUTED BENZENE FUNGICIDES | DU PONT (US) | 2012-12-05 | — | — | EP | claimed |
| US-20100120714-A1 | SUBSTITUTED BENZENE FUNGICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-05-13 | — | — | US | claimed |
| US-9743667-B2 | Substituted benzene fungicides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2017-08-29 | — | — | US | disclosed |
| US-9198433-B2 | Substituted benzene fungicides | E I DU PONT DE NEMOURS AND COMPANY (US) | 2015-12-01 | — | — | US | disclosed |
| US-20150335023-A1 | SUBSTITUTED BENZENE FUNGICIDES | FMC CORPORATION | 2015-11-26 | — | — | US | disclosed |
| US-20140323436-A1 | SUBSTITUTED BENZENE FUNGICIDES | FMC CORPORATION | 2014-10-30 | — | — | US | disclosed |
| US-8822521-B2 | Substituted benzene fungicides | E I DU PONT DE NEMOURS AND COMPANY (DE) | 2014-09-02 | — | — | US | disclosed |
| EP-2129225-B1 | SUBSTITUTED BENZENE FUNGICIDES | DU PONT (US) | 2012-12-05 | — | — | EP | disclosed |
| US-20100120714-A1 | SUBSTITUTED BENZENE FUNGICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150335023-A1 | SUBSTITUTED BENZENE FUNGICIDES | NR0B1, CBR3, NR0B2 | TSHR 1053/4885WDR5 1471/4885ROCK2 3310/4885 |
| US-20140323436-A1 | SUBSTITUTED BENZENE FUNGICIDES | NR0B1, CBR3, NR0B2 | TSHR 1053/4885WDR5 1471/4885ROCK2 3310/4885 |
| US-20100120714-A1 | SUBSTITUTED BENZENE FUNGICIDES | NR0B1, CBR3, NR0B2 | TSHR 1039/4885WDR5 1427/4885ROCK2 3214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.