Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 16/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 9/20 | 0.55 |
| ▸ | CASP7 | P55210 | 8/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324425 | 0.95 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL3324526 | 0.92 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL5332348 | 0.92 | KDM4E (0.51) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL5478346 | 0.91 | KDM4E (0.72) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL3324836 | 0.89 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL3329937 | 0.87 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL3323761 | 0.87 | KDM4E (0.62) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL3323592 | 0.86 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL3326694 | 0.86 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDGAAPOLB | |
| SCHEMBL14508415 | 0.86 | KDM4E (0.62) | ALDH1A1KDM4EHPGDGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | APP, MAPT, PSEN1 | ALDH1A1 2615/4885KDM4E 4115/4885HPGD 265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.