Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324520 | 1.00 | HRH3 (0.56) | HRH3L3MBTL1KCNH2 | |
| SCHEMBL3325886 | 1.00 | HRH3 (0.56) | HRH3L3MBTL1KCNH2 | |
| SCHEMBL3327455 | 0.97 | HRH3 (0.53) | HRH3L3MBTL1KCNH2 | |
| SCHEMBL3330189 | 0.96 | HRH3 (0.52) | HRH3L3MBTL1KCNH2 | |
| SCHEMBL3324027 | 0.96 | HRH3 (0.52) | HRH3L3MBTL1KCNH2 | |
| SCHEMBL3324024 | 0.96 | HRH3 (0.52) | HRH3L3MBTL1KCNH2 | |
| SCHEMBL3330185 | 0.96 | HRH3 (0.52) | HRH3L3MBTL1KCNH2 | |
| SCHEMBL3326101 | 0.89 | MEN1 (0.48) | HRH3 | |
| SCHEMBL3326099 | 0.89 | MEN1 (0.48) | HRH3 | |
| SCHEMBL3326452 | 0.88 | LMNA (0.52) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100120769-A1 | CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES | NETTEKOVEN MATTHIAS | 2010-05-13 | — | — | US | claimed |
| US-20070167436-A1 | Cyclohexyl piperazinyl methanone derivatives | HOFFMANN-LA ROCHE INC. | 2007-07-19 | — | — | US | claimed |
| US-20100120769-A1 | CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES | NETTEKOVEN MATTHIAS | 2010-05-13 | — | — | US | disclosed |
| US-20070167436-A1 | Cyclohexyl piperazinyl methanone derivatives | HOFFMANN-LA ROCHE INC. | 2007-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120769-A1 | CYCLOHEXYL PIPERAZINYL METHANONE DERIVATIVES | HRH3, HRH4, HRH1 | HRH3 1/4885L3MBTL1 3512/4885KCNH2 455/4885 |
| US-20070167436-A1 | Cyclohexyl piperazinyl methanone derivatives | HRH3, HRH4, HRH1 | HRH3 1/4885L3MBTL1 3512/4885KCNH2 455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.