Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 5/20 | 0.57 |
| ▸ | CASP7 | P55210 | 5/20 | 0.57 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12784576 | 0.90 | ALDH1A1 (0.64) | ALDH1A1KDM4ESMN1; SMN2MAPK1CASP1 | |
| SCHEMBL3323156 | 0.88 | KDM4E (0.66) | ALDH1A1KDM4ESMN1; SMN2MAPK1CASP1 | |
| SCHEMBL3320728 | 0.86 | FFAR3 (0.61) | ALDH1A1KDM4ESMN1; SMN2MAPK1CASP1 | |
| SCHEMBL3323328 | 0.85 | KDM4E (0.58) | ALDH1A1KDM4ESMN1; SMN2MAPK1CASP1 | |
| SCHEMBL3324117 | 0.84 | KDM4E (0.61) | ALDH1A1KDM4ESMN1; SMN2MAPK1CASP1 | |
| SCHEMBL3324018 | 0.84 | SMN1; SMN2 (0.58) | ALDH1A1KDM4ESMN1; SMN2MAPK1CASP1 | |
| SCHEMBL3329777 | 0.81 | ALDH1A1 (0.78) | ALDH1A1KDM4ESMN1; SMN2MAPK1CASP1 | |
| SCHEMBL3322507 | 0.80 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2MAPK1CASP1 | |
| SCHEMBL3325524 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KDM4ESMN1; SMN2MAPK1CASP1 | |
| SCHEMBL2992233 | 0.79 | SMN1; SMN2 (0.77) | ALDH1A1KDM4ESMN1; SMN2MAPK1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | APP, MAPT, PSEN1 | ALDH1A1 2615/4885KDM4E 4115/4885SMN1; SMN2 1086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.