Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 16/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.63 |
| ▸ | GAA | P10253 | 9/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.63 |
| ▸ | HPGD | P15428 | 8/20 | 0.63 |
| ▸ | CASP1 | P29466 | 7/20 | 0.63 |
| ▸ | CASP7 | P55210 | 6/20 | 0.63 |
| ▸ | GLA | P06280 | 3/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 2/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NOTCH1 | P46531 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5815747 | 0.88 | NPSR1 (0.67) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL23008930 | 0.88 | KDM4E (0.57) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL3323951 | 0.87 | KDM4E (0.70) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL3328880 | 0.85 | KDM4E (0.65) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL5810346 | 0.85 | HTR1A (0.50) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL12135787 | 0.84 | KDM4E (0.65) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL8186663 | 0.83 | GSK3B (0.55) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL17194877 | 0.82 | KDM4E (0.63) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL3016247 | 0.81 | MAPK1 (0.70) | KDM4EALDH1A1GAAHSD17B10HPGD | |
| SCHEMBL13333236 | 0.80 | KDM4E (0.71) | KDM4EALDH1A1GAAHSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | APP, MAPT, PSEN1 | KDM4E 4115/4885ALDH1A1 2615/4885GAA 271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.