Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dextromethorphan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2A known ✓ | Q12879 | 7/20 | 0.98 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 6/20 | 0.98 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.98 |
| ▸ | GRIN2D | O15399 | 6/20 | 0.98 |
| ▸ | GRIN3B | O60391 | 6/20 | 0.98 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.98 |
| ▸ | GRIN2C | Q14957 | 6/20 | 0.98 |
| ▸ | GRIN3A | Q8TCU5 | 6/20 | 0.98 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.98 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.98 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextromethorphan SCHEMBL570724 | 0.99 | CYP2D6 (0.96) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Dextromethorphan SCHEMBL29359586 | 0.99 | CYP2D6 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Racemethorphan SCHEMBL4894005 | 0.99 | CYP2D6 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Dextromethorphan SCHEMBL1321395 | 0.99 | CYP2D6 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Dextromethorphan SCHEMBL4532860 | 0.99 | CYP2D6 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Racemethorphan SCHEMBL30052214 | 0.99 | CYP2D6 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Levomethorphan SCHEMBL4910539 | 0.99 | CYP2D6 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Dextromethorphan SCHEMBL121923 | 0.99 | CYP2D6 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Racemethorphan SCHEMBL7380035 | 0.99 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B | |
| Racemethorphan SCHEMBL20809259 | 0.99 | GRIN1 (1.00) | GRIN1GRIN2AGRIN2DGRIN3BGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117100750-A | Pharmaceutical composition and application thereof | 深圳信立泰药业股份有限公司 | 2023-11-24 | — | — | CN | disclosed |
| CN-116459255-A | Use of deuterated dextromethorphan and bupropion in combination in preparation of AD (analog to digital) excitation drugs | 深圳信立泰药业股份有限公司 | 2023-07-21 | — | — | CN | disclosed |
| WO-2022228363-A1 | MEDICAL USE OF COMPOSITION | 杭州剂泰医药科技有限责任公司 | 2022-11-03 | — | — | WO | disclosed |
| CN-115245515-A | Medical application of composition | 杭州剂泰医药科技有限责任公司 | 2022-10-28 | — | — | CN | disclosed |
| CN-114340608-A | Pharmaceutical composition and application thereof | 深圳信立泰药业股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| US-9272037-B2 | Method to treat premature ejaculation in humans | TRINITY LABORATORIES, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| US-20140296262-A1 | Method to Treat Premature Ejaculation in Humans | TRINITY LABORATORIES, INC. (US) | 2014-10-02 | — | — | US | disclosed |
| US-8604082-B2 | Method to treat premature ejaculation in humans | TRINITY LABORATORIES, INC. (US) | 2013-12-10 | — | — | US | disclosed |
| US-7754767-B2 | Method for treatment of premature ejaculation in humans | TRINITY LABORATORIES, INC. (US) | 2010-07-13 | — | — | US | disclosed |
| US-20100120780-A1 | TREATMENTS FOR PREMATURE EJACULATION IN HUMANS | TRINITY LABORATORIES INC. | 2010-05-13 | — | — | US | disclosed |
| US-20090215810-A1 | Method to Treat Premature Ejaculation in Humans | TRINITY LABORATORIES, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| EP-1969117-A4 | A METHOD TO TREAT PREMATURE EJACULATION IN HUMANS | TRINITY LAB INC (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2008131256-A1 | IMPROVED TREATMENTS FOR PREMATURE EJACULATION IN HUMANS | TRINITY LABORATORIES INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| EP-1969117-A2 | A METHOD TO TREAT PREMATURE EJACULATION IN HUMANS | Trinity Laboratories, Inc. (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007070779-A2 | A METHOD TO TREAT PREMATURE EJACULATION IN HUMANS | TRINITY LABORATORIES, INC. (US) | 2007-06-21 | — | — | WO | disclosed |
| US-20040235954-A1 | Method for treatment of premature ejaculation in humans | JEFFERSON BANK | 2004-11-25 | — | — | US | disclosed |