Pentamidine

Pentamidine

SCHEMBL3329

N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 3/20 1.00
F2 P00734 2/20 1.00
ST14 Q9Y5Y6 2/20 1.00
TMPRSS2 O15393 2/20 1.00
PLAU P00749 1/20 1.00
PRMT5 O14744 1/20 1.00
SLC22A2 O15244 1/20 1.00
SLC22A1 O15245 1/20 1.00
PTP4A3 O75365 1/20 1.00
SLC22A3 O75751 1/20 1.00
F10 P00742 1/20 1.00
PLG P00747 1/20 1.00
S100B P04271 1/20 1.00
CHRM2 P08172 1/20 1.00
CHRM4 P08173 1/20 1.00
CHRM5 P08912 1/20 1.00
ADRA2A P08913 1/20 1.00
CYP2D6 P10635 1/20 1.00
AOC1 P19801 1/20 1.00
MAOA P21397 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14599628 1.00 PRMT1 (1.00) PRMT1F2ST14TMPRSS2PLAU
SCHEMBL14599631 1.00 PRMT1 (1.00) PRMT1F2ST14TMPRSS2PLAU
Heptamidine SCHEMBL14599630 1.00 PRMT1 (1.00) PRMT1F2ST14TMPRSS2PLAU
Hexamidine SCHEMBL144738 1.00 PRMT1 (1.00) PRMT1F2ST14TMPRSS2PLAU
SCHEMBL14599639 1.00 PRMT1 (1.00) PRMT1F2ST14TMPRSS2PLAU
Pentamidine SCHEMBL3227 0.98 PRSS1 (1.00) PRMT1F2ST14TMPRSS2PLAU
Hexamidine SCHEMBL306398 0.98 PRMT1 (0.96) PRMT1F2ST14TMPRSS2PLAU
Pentamidine SCHEMBL7060561 0.98 PRSS1 (1.00) PRMT1F2ST14TMPRSS2PLAU
Hexamidine SCHEMBL3629982 0.98 PRSS1 (1.00) PRMT1F2ST14TMPRSS2PLAU
Hexamidine SCHEMBL18701066 0.98 PRMT1 (0.96) PRMT1F2ST14TMPRSS2PLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 29154 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122094963-A Cardioprotective lipids and methods of use 2026-05-26 CN claimed
US-20260132153-A1 METHOD FOR PREPARING AND PURIFYING 4-BORONO-L-PHENYLALANINE SCI PHARMTECH, INC. (TW) 2026-05-14 US claimed
CN-122028945-A Apparatus, systems, and methods for aerosolized drug administration GH研究爱尔兰有限公司 2026-05-12 CN claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
US-12617809-B2 Cardioprotective lipid and method of use SIGNPATH PHARMA, INC. (US) 2026-05-05 US claimed
US-20260091119-A1 ISOLATED TARGETED DELIVERY SYSTEM FOR THE TREATMENT OF GLIOMA CELLIS AG (CH) 2026-04-02 US claimed
US-20250382261-A1 PENTAMIDINE ANALOGS THE BROAD INSTITUTE, INC. (US) 2025-12-18 US claimed
WO-2025242918-A1 PENTAMIDINE FOR USE IN THE TREATMENT OR PREVENTION OF SEXUALLY TRANSMITTED INFECTIONS CAUSED BY CHLAMYDIA SPP. OR NEISSERIA SPP. MEDIZINISCHE UNIVERSITÄT WIEN (AT) 2025-11-27 WO claimed
US-20250361205-A1 ENZYME-CLEAVABLE METHADONE PRODRUGS AND METHODS OF USE THEREOF ENSYSCE BIOSCIENCES INC (US) 2025-11-27 US claimed
US-12474326-B2 Treatment methods having reduced drug-related toxicity and methods of identifying the likelihood of patient harm from prescribed medications TABULA RASA HEALTHCARE, INC. (US) 2025-11-18 US claimed
US-4895719-A SUSPENSION, ENCAPSULATION, DRUG DELIVERY LIPOSOME TECHNOLOGY, INC. (US) 1990-01-23 US claimed
EP-0345926-A1 Pharmaceutical compositions containing pentamidine FISONS CORPORATION (US) 1989-12-13 EP claimed
WO-1989008658-A1 SUBSTITUTED ADENINE DERIVATIVES USEFUL AS THERAPEUTIC AGENTS SCRIPPS CLINIC AND RESEARCH FOUNDATION (US) 1989-09-21 WO claimed
US-4853416-A TREATING PNEUMO-CYSTIS CARINII PNEUMONIA; AIDS; FISONS CORPORATION (GB) 1989-08-01 US claimed
EP-0315467-A2 Pentamidine salts useful in the treatment and prophylaxis of pneumocystis carinii pneumonia LyphoMed, Inc. (US) 1989-05-10 EP claimed
US-4823784-A Aerosol inhalation apparatus CADEMA MEDICAL PRODUCTS, INC. (US) 1989-04-25 US claimed
EP-0309519-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING PENTAMIDINE. FISONS PLC (GB) 1989-04-05 EP claimed
EP-0292100-A1 Composition for the prophylaxis or treatment of pneumocystis carinii pneumonia Sloan-Kettering Institute For Cancer Research (US) 1988-11-23 EP claimed
WO-1988007855-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING PENTAMIDINE FISONS PLC (GB) 1988-10-20 WO claimed
US-4399151-A USING A-SUBSTITUTERD AMINES OR A-SUBSTITUTED AMINO ACIDS MERRELL DOW PHARMACEUTICALS INC. (US) 1983-08-16 US claimed