Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Verapamil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 3/20 | 0.98 |
| ▸ | CACNA1F known ✓ | O60840 | 2/20 | 0.98 |
| ▸ | CACNA1D known ✓ | Q01668 | 2/20 | 0.98 |
| ▸ | CACNA1S known ✓ | Q13698 | 2/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.98 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.98 |
| ▸ | HTR1A | P08908 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexverapamil SCHEMBL8759750 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2ALMNATSHR | |
| (S)-Verapamil SCHEMBL8759334 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2ALMNATSHR | |
| Verapamil SCHEMBL1869012 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2ALMNATSHR | |
| Verapamil SCHEMBL1801539 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2ALMNATSHR | |
| Verapamil SCHEMBL1172818 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2ALMNATSHR | |
| Verapamil SCHEMBL17598055 | 0.99 | CYP3A4 (0.98) | CYP3A4MEN1KMT2ALMNATSHR | |
| Dexverapamil SCHEMBL33297 | 0.99 | ABCB1 (1.00) | CYP3A4MEN1KMT2ALMNATSHR | |
| Verapamil SCHEMBL16742 | 0.99 | ABCB1 (1.00) | CYP3A4MEN1KMT2ALMNATSHR | |
| Verapamil SCHEMBL1902363 | 0.99 | ABCB1 (1.00) | CYP3A4MEN1KMT2ALMNATSHR | |
| Verapamil SCHEMBL29450364 | 0.99 | ABCB1 (1.00) | CYP3A4MEN1KMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 13766 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12618929-B2 | Navigational beaconing via doppler null scanning (DNS) | ROCKWELL COLLINS, INC. (US) | 2026-05-05 | — | — | US | claimed |
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| EP-4680201-A1 | COMPOSITIONS AND USES THEREOF FOR STABILIZATION OF BLOOD SAMPLE COMPONENTS | Streck LLC (US) | 2026-01-21 | — | — | EP | claimed |
| US-12478586-B2 | Small molecular drug-loaded polymer vesicle, preparation method therefor and use thereof | SOOCHOW UNIVERSITY (CN) | 2025-11-25 | — | — | US | claimed |
| US-12433899-B2 | Therapeutics and method for treating osteoarthritis | CALOSYN PHARMA INC. (US) | 2025-10-07 | — | — | US | claimed |
| EP-4623241-A1 | ADAPTER FOR SUSPENDING LAMPS | Berg, Karin (DE) | 2025-10-01 | — | — | EP | claimed |
| US-20250269005-A1 | METHODS FOR TREATING, AMELIORATING OR PREVENTING INFECTIONS USING DRUG AND VACCINATION COMBINATION TREATMENT | TOPELIA AUST LIMITED (ACN 652 771 670) (AU) | 2025-08-28 | — | — | US | claimed |
| WO-2025131019-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF INHIBIN SUBUNIT BETA E (INHBE) | SHANGHAI ARGO BIOPHARMACEUTICAL CO., LTD. (CN) | 2025-06-26 | — | — | WO | claimed |
| CN-115536547-B | Preparation method of verapamil hydrochloride | 北京新领先医药科技发展有限公司 | 2025-06-13 | — | — | CN | claimed |
| CN-120076796-A | Oral pharmaceutical dosage form for gastric retention | 南京三迭纪医药科技有限公司 | 2025-05-30 | — | — | CN | claimed |
| EP-0265757-A2 | Method and arrangement for rolling continuously cast profiles | SMS SCHLOEMANN-SIEMAG AKTIENGESELLSCHAFT (DE) | 1988-05-04 | — | — | EP | claimed |
| EP-0241472-A1 | FAST SELF RIGHTING CATAMARAN | PETROVICH, Enrique, G. (US) | 1987-10-21 | — | — | EP | claimed |
| EP-0236459-A1 | AEROSOL MIXING AND APPLICATION GUN | Henkel Kommanditgesellschaft auf Aktien (DE) | 1987-09-16 | — | — | EP | claimed |
| EP-0125326-B1 | NUCLEAR REACTOR | WESTINGHOUSE ELECTRIC CORPORATION (US) | 1987-09-09 | — | — | EP | claimed |
| WO-1987002320-A1 | FAST SELF RIGHTING CATAMARAN | PETROVICH ENRIQUE G (US) | 1987-04-23 | — | — | WO | claimed |
| WO-1987001680-A1 | AEROSOL MIXING AND APPLICATION GUN | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1987-03-26 | — | — | WO | claimed |
| EP-0214062-A1 | Method for making non-woven fabrics with a nap laid by needling | BENOIT LE TAPIS BROSSE (Société anonyme de droit francais) (FR) | 1987-03-11 | — | — | EP | claimed |
| EP-0065533-B1 | METHOD FOR ROLLING A U-SHAPED STEEL BAR OR SIMILAR AND BEAM-MAKING UNIVERSAL MILL TRAIN FOR IMPLEMENTING SUCH METHOD | MANNESMANN Aktiengesellschaft (DE) | 1985-04-10 | — | — | EP | claimed |
| US-4413322-A | Automatic waypoint area navigation system | FOSTER AIRDATA SYSTEMS INC. (US) | 1983-11-01 | — | — | US | claimed |
| EP-0068560-A2 | Mowing device | Multinorm B.V. (NL) | 1983-01-05 | — | — | EP | claimed |