Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dexverapamil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 3/20 | 1.00 |
| ▸ | CACNA1F known ✓ | O60840 | 2/20 | 1.00 |
| ▸ | CACNA1D known ✓ | Q01668 | 2/20 | 1.00 |
| ▸ | CACNA1S known ✓ | Q13698 | 2/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 9/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | ABCC1 | P33527 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Verapamil SCHEMBL29450374 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| (S)-Verapamil SCHEMBL29768846 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Dexverapamil SCHEMBL30402443 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Verapamil SCHEMBL29450364 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Verapamil SCHEMBL29064783 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Verapamil SCHEMBL16742 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Dexverapamil SCHEMBL29423253 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Verapamil SCHEMBL1902363 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| Verapamil SCHEMBL29440902 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR | |
| (S)-Verapamil SCHEMBL14874635 | 1.00 | ABCB1 (1.00) | ABCB1CYP3A4ABCC1KCNH2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 15312 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260116861-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-04-30 | — | — | US | claimed |
| EP-4691556-A2 | HUMANIZED ANTI-ACTH ANTIBODIES AND USE THEREOF | H. Lundbeck A/S (DK) | 2026-02-11 | — | — | EP | claimed |
| US-12522572-B2 | Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2026-01-13 | — | — | US | claimed |
| EP-4623241-A1 | ADAPTER FOR SUSPENDING LAMPS | Berg, Karin (DE) | 2025-10-01 | — | — | EP | claimed |
| US-20250269005-A1 | METHODS FOR TREATING, AMELIORATING OR PREVENTING INFECTIONS USING DRUG AND VACCINATION COMBINATION TREATMENT | TOPELIA AUST LIMITED (ACN 652 771 670) (AU) | 2025-08-28 | — | — | US | claimed |
| WO-2025080879-A1 | BRIDGED TRICYCLIC CARBAMOYLPYRIDONE COMPOUNDS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2025-04-17 | — | — | WO | claimed |
| WO-2025050228-A1 | PHARMACEUTICAL COMPOSITION COMPRISING A PEPTIDE OR A COMBINATION OF PEPTIDES AGONISTIC TO THE MAS, AT1 AND AT2 RECEPTORS | PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE (CL) | 2025-03-13 | — | — | WO | claimed |
| US-20250032503-A1 | USE OF APREPITANT FOR TREATING ALZHEIMER'S DISEASE | HOTH THERAPEUTICS, INC. | 2025-01-30 | — | — | US | claimed |
| US-20240343697-A1 | ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2024-10-17 | — | — | US | claimed |
| WO-2024110384-A1 | ADAPTER FOR SUSPENDING LAMPS | BERG KARIN (DE) | 2024-05-30 | — | — | WO | claimed |
| EP-0282368-A1 | Polyurethane-based compositions for the preparation of bio-degradable materials by calandering | PENNEL et FLIPO (FR) | 1988-09-14 | — | — | EP | claimed |
| EP-0265757-A2 | Method and arrangement for rolling continuously cast profiles | SMS SCHLOEMANN-SIEMAG AKTIENGESELLSCHAFT (DE) | 1988-05-04 | — | — | EP | claimed |
| EP-0241472-A1 | FAST SELF RIGHTING CATAMARAN | PETROVICH, Enrique, G. (US) | 1987-10-21 | — | — | EP | claimed |
| EP-0236459-A1 | AEROSOL MIXING AND APPLICATION GUN | Henkel Kommanditgesellschaft auf Aktien (DE) | 1987-09-16 | — | — | EP | claimed |
| EP-0125326-B1 | NUCLEAR REACTOR | WESTINGHOUSE ELECTRIC CORPORATION (US) | 1987-09-09 | — | — | EP | claimed |
| WO-1987002320-A1 | FAST SELF RIGHTING CATAMARAN | PETROVICH ENRIQUE G (US) | 1987-04-23 | — | — | WO | claimed |
| WO-1987001680-A1 | AEROSOL MIXING AND APPLICATION GUN | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1987-03-26 | — | — | WO | claimed |
| EP-0214062-A1 | Method for making non-woven fabrics with a nap laid by needling | BENOIT LE TAPIS BROSSE (Société anonyme de droit francais) (FR) | 1987-03-11 | — | — | EP | claimed |
| EP-0065533-B1 | METHOD FOR ROLLING A U-SHAPED STEEL BAR OR SIMILAR AND BEAM-MAKING UNIVERSAL MILL TRAIN FOR IMPLEMENTING SUCH METHOD | MANNESMANN Aktiengesellschaft (DE) | 1985-04-10 | — | — | EP | claimed |
| EP-0068560-A2 | Mowing device | Multinorm B.V. (NL) | 1983-01-05 | — | — | EP | claimed |