Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 2/20 | 0.36 |
| ▸ | PTAFR | P25105 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3329282 | 0.83 | SMN1; SMN2 (0.40) | L3MBTL1EPHX2ALDH1A1LMNAHPGD | |
| SCHEMBL3332841 | 0.83 | SMN1; SMN2 (0.40) | L3MBTL1EPHX2ALDH1A1LMNAHPGD | |
| SCHEMBL26102567 | 0.75 | HPGD (0.32) | HPGDSMN1; SMN2PDK2 | |
| SCHEMBL3329458 | 0.74 | KDM4E (0.36) | L3MBTL1EPHX2ALDH1A1LMNAHPGD | |
| SCHEMBL19096874 | 0.71 | EPHX2 (0.62) | L3MBTL1EPHX2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3328737 | 0.68 | TSHR (0.33) | EPHX2ALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL3329277 | 0.68 | SMN1; SMN2 (0.43) | L3MBTL1ALDH1A1SMN1; SMN2USP2TSHR | |
| SCHEMBL3328458 | 0.68 | SMN1; SMN2 (0.43) | L3MBTL1ALDH1A1SMN1; SMN2USP2TSHR | |
| SCHEMBL3332875 | 0.68 | SMN1; SMN2 (0.43) | L3MBTL1ALDH1A1SMN1; SMN2USP2TSHR | |
| SCHEMBL17799020 | 0.66 | HSD11B1 (0.42) | ALDH1A1HPGDHSD17B10USP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137316-A1 | Morpholine Compounds, Pharmaceutically Acceptable Salts Thereof, Pharmaceutical Compositions, and Methods Of Use Thereof | FISH PAUL VINCENT | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137316-A1 | Morpholine Compounds, Pharmaceutically Acceptable Salts Thereof, Pharmaceutical Compositions, and Methods Of Use Thereof | OPRL1, UGT1A1, HTR3B | L3MBTL1 3961/4885EPHX2 3467/4885ALDH1A1 690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.