Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.59 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SLC47A1 | Q96FL8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ATP4A | P20648 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ATP4B | P51164 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Impromidine SCHEMBL11039350 | 1.00 | HRH2 (0.59) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| Impromidine SCHEMBL11074839 | 0.99 | HRH2 (0.58) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| SCHEMBL9865975 | 0.95 | HRH2 (0.61) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| Hydrochloric Acid SCHEMBL9866459 | 0.94 | HRH2 (0.60) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| Impromidine SCHEMBL9771045 | 0.92 | HRH2 (0.70) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| Impromidine SCHEMBL11726207 | 0.91 | HRH2 (0.69) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| SCHEMBL9866646 | 0.90 | HRH2 (0.62) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| Hydrochloric Acid SCHEMBL9867604 | 0.89 | HRH2 (0.61) | HRH2HRH4HRH3L3MBTL1SLC47A1 | |
| SCHEMBL7179454 | 0.88 | HRH4 (0.46) | HRH2HRH4HRH3 | |
| SCHEMBL11040550 | 0.88 | HRH4 (0.48) | HRH2HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655914-B1 | Use of Histamine-2 agonists for treatment of sexual dysfunction | NAHOUM CESAR ROBERTO DIAS (BR) | 2003-02-26 | — | — | EP | claimed |
| US-20130059878-A1 | TREATMENT OF DISEASES MODULATED BY A H4 RECEPTOR AGONIST | LORIA EMILE (US) | 2013-03-07 | — | — | US | disclosed |
| US-8207188-B2 | Treatment of diseases modulated by a H4 receptor agonist | NICOLAOU MICHALIS (US) | 2012-06-26 | — | — | US | disclosed |
| US-20100144718-A1 | TREATMENT OF DISEASES MODULATED BY A H4 RECEPTOR AGONIST | NICOLAOU MICHALIS | 2010-06-10 | — | — | US | disclosed |
| EP-1117405-A2 | COMPOSITION AND METHOD FOR TREATING ALLERGIC DISEASES | SCHERING CORPORATION (US) | 2001-07-25 | — | — | EP | disclosed |
| US-6103735-A | IN COMBINATION, ANTAGONISTS OF A NEUORKININ, A HISTAMINE 3 AND A HISTAMINE 1; ANTIALLERGENS; RHINITIS, ASTHMA AND RELATED DISORDERS; COUGH, WHEEZING; SNEEZING, ITCHING, RUNNY NOSE, NASAL CONGESTION, REDNESS OF THE EYE, TEARING | SCHERING CORPORATION (US) | 2000-08-15 | — | — | US | disclosed |
| WO-2000021512-A2 | COMPOSITION AND METHOD FOR TREATING ALLERGIC DISEASES | SCHERING CORPORATION (US) | 2000-04-20 | — | — | WO | disclosed |
| EP-0041359-B1 | PROCESS FOR THE PREPARATION OF HETEROCYCLYLALKYL GUANIDINES; INTERMEDIATES AND THEIR PREPARATION | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-11-14 | — | — | EP | disclosed |
| US-4443375-A | Tetrahydroimidazo(3,4-c)-1,3-diazocine intermediates for production of guanidines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-04-17 | — | — | US | disclosed |
| US-4443375-A | Tetrahydroimidazo(3,4-c)-1,3-diazocine intermediates for production of guanidines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-04-17 | — | — | US | disclosed |
| US-4375435-A | 3-,4-Dihydroimidazo (3,4-c)-1,3-pyrimidines and 4,5-dihydroimidazo (3,4-c)-1,3-diazepines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-03-01 | — | — | US | disclosed |
| US-4375435-A | 3-,4-Dihydroimidazo (3,4-c)-1,3-pyrimidines and 4,5-dihydroimidazo (3,4-c)-1,3-diazepines | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-03-01 | — | — | US | disclosed |
| EP-0041359-A1 | Process for the preparation of heterocyclylalkyl guanidines; intermediates and their preparation | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-09 | — | — | EP | disclosed |
| EP-0041359-A1 | Process for the preparation of heterocyclylalkyl guanidines; intermediates and their preparation | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-12-09 | — | — | EP | disclosed |