Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.48 |
| ▸ | HRH2 | P25021 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11040543 | 0.91 | HRH4 (0.52) | HRH4HRH3HRH2HRH1TDP1 | |
| SCHEMBL11040540 | 0.91 | HRH4 (0.52) | HRH4HRH3HRH2HRH1TDP1 | |
| Impromidine SCHEMBL11039350 | 0.88 | HRH2 (0.59) | HRH4HRH3HRH2 | |
| Impromidine SCHEMBL3334460 | 0.88 | HRH2 (0.59) | HRH4HRH3HRH2 | |
| SCHEMBL9865975 | 0.87 | HRH2 (0.61) | HRH4HRH3HRH2 | |
| Impromidine SCHEMBL11074839 | 0.87 | HRH2 (0.58) | HRH4HRH3HRH2 | |
| Hydrochloric Acid SCHEMBL9866459 | 0.86 | HRH2 (0.60) | HRH4HRH3HRH2 | |
| Impromidine SCHEMBL9771045 | 0.83 | HRH2 (0.70) | HRH4HRH3HRH2 | |
| Impromidine SCHEMBL11726207 | 0.83 | HRH2 (0.69) | HRH4HRH3HRH2 | |
| SCHEMBL11039962 | 0.82 | SIGMAR1 (0.41) | HRH4HRH3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0041359-B1 | PROCESS FOR THE PREPARATION OF HETEROCYCLYLALKYL GUANIDINES; INTERMEDIATES AND THEIR PREPARATION | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1984-11-14 | — | — | EP | disclosed |