Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Paroxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | GRK2 | P25098 | 4/20 | 0.98 |
| ▸ | TP53 | P04637 | 2/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.98 |
| ▸ | THPO | P40225 | 1/20 | 0.98 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.98 |
| ▸ | NPC1 | O15118 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paroxetine SCHEMBL9398356 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2AUSP2GRK2 | |
| Paroxetine SCHEMBL9398351 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2AUSP2GRK2 | |
| Paroxetine SCHEMBL2847926 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2AUSP2GRK2 | |
| Paroxetine SCHEMBL6100418 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2AUSP2GRK2 | |
| Paroxetine SCHEMBL29437926 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2AUSP2GRK2 | |
| Paroxetine SCHEMBL5312626 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2AUSP2GRK2 | |
| Paroxetine SCHEMBL3854638 | 1.00 | CYP3A4 (1.00) | CYP3A4MEN1KMT2AUSP2GRK2 | |
| Paroxetine SCHEMBL145268 | 0.99 | CYP3A4 (1.00) | CYP3A4MEN1KMT2AUSP2GRK2 | |
| Paroxetine SCHEMBL8184989 | 0.99 | CYP3A4 (0.98) | CYP3A4MEN1KMT2AUSP2GRK2 | |
| Paroxetine SCHEMBL145267 | 0.99 | CYP3A4 (1.00) | CYP3A4MEN1KMT2AUSP2GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4356 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12599596-B2 | Anti-tumor pharmaceutical composition based on immune checkpoint blockade and use thereof | SHANGHAI HUI TIAN JIN ZE BIOTECH CO., LTD. (CN) | 2026-04-14 | — | — | US | claimed |
| US-20250275924-A1 | Anticholinergic Agents and Muscarinic Agonists for the Treatment of Demodex Related Conditions | ATTILLAPS HOLDINGS INC. | 2025-09-04 | — | — | US | claimed |
| CN-120157611-A | Preparation method of paroxetine hydrochloride intermediate | 甘肃皓天科技股份有限公司 | 2025-06-17 | — | — | CN | claimed |
| EP-4566590-A1 | TASTE-MASKING MICROSPHERE, PREPARATION PROCESS THEREFOR, AND USE THEREOF | Harbin Kanon Pharmaceutical Co., Ltd (CN) | 2025-06-11 | — | — | EP | claimed |
| US-20250127769-A1 | ANTI-TUMOR PHARMACEUTICAL COMPOSITION BASED ON IMMUNE CHECKPOINT BLOCKADE AND USE THEREOF | SHANGHAI HUI TIAN JIN ZE BIOTECH CO., LTD. (CN) | 2025-04-24 | — | — | US | claimed |
| CN-119838119-A | Victim emotion regulating system based on self-care | 郑州师范学院 | 2025-04-18 | — | — | CN | claimed |
| WO-2025044424-A1 | ANTI-TUMOR PHARMACEUTICAL COMPOSITION BASED ON IMMUNE CHECKPOINT BLOCKING AND USE THEREOF | 上海彗天锦泽生物医学科技有限公司 | 2025-03-06 | — | — | WO | claimed |
| EP-4511123-A1 | ANTICHOLINERGIC AGENTS AND MUSCARINIC AGONISTS FOR THE TREATMENT OF DEMODEX RELATED CONDITIONS | Attillaps Holdings Inc. (US) | 2025-02-26 | — | — | EP | claimed |
| CN-119384294-A | Anticholinergic agents and muscarinic agonists for the treatment of Demodex related conditions | 阿提莱普斯控股有限公司 | 2025-01-28 | — | — | CN | claimed |
| CN-117503707-B | Taste-masking microsphere and preparation process and application thereof | 哈尔滨市康隆药业有限责任公司 | 2024-08-23 | — | — | CN | claimed |
| US-5276042-A | Treatment of premature ejaculation | CRENSHAW ROGER T (US) | 1994-01-04 | — | — | US | claimed |
| EP-0269303-B1 | PIPERIDINE DERIVATIVE FOR TREATING PAIN | NOVO NORDISK A/S (DK) | 1993-08-04 | — | — | EP | claimed |
| EP-0223403-B1 | PIPERIDINE DERIVATIVE, ITS PREPARATION, AND ITS USE AS MEDICAMENT | BEECHAM GROUP PLC (GB) | 1993-08-04 | — | — | EP | claimed |
| EP-0188081-B1 | USE OF PAROXETINE FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 1992-03-11 | — | — | EP | claimed |
| US-4804669-A | Treatment of pain with a piperidine | A/S FERROSAN (DK) | 1989-02-14 | — | — | US | claimed |
| EP-0269303-A2 | Piperidine derivative for treating pain | NOVO NORDISK A/S (DK) | 1988-06-01 | — | — | EP | claimed |
| US-4745122-A | PAROXETINE ADMINISTERED TO ANIMALS | A/S FERROSAN (DK) | 1988-05-17 | — | — | US | claimed |
| US-4721723-A | TRANS-4-(4'FLUOROPHENYL)3-(3',4' METHYLENEDIOXY PHENOXY METHYL PIPERIDINE | BEECHAM GROUP P.L.C. (GB) | 1988-01-26 | — | — | US | claimed |
| EP-0223403-A2 | Piperidine derivative, its preparation, and its use as medicament | BEECHAM GROUP PLC (GB) | 1987-05-27 | — | — | EP | claimed |
| EP-0188081-A2 | Use of paroxetine for the manufacture of a medicament for the treatment of obesity | NOVO NORDISK A/S (DK) | 1986-07-23 | — | — | EP | claimed |