Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Paroxetine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | GRK2 | P25098 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | TP53 | P04637 | 2/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | THPO | P40225 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.96 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.96 |
| ▸ | NPC1 | O15118 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Paroxetine SCHEMBL27521044 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2MEN1KMT2ATP53 | |
| Paroxetine SCHEMBL145267 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2MEN1KMT2ATP53 | |
| Paroxetine SCHEMBL145268 | 1.00 | CYP3A4 (1.00) | CYP3A4GRK2MEN1KMT2ATP53 | |
| Paroxetine SCHEMBL27386741 | 0.99 | CYP3A4 (0.98) | CYP3A4GRK2MEN1KMT2ATP53 | |
| Paroxetine SCHEMBL33348 | 0.99 | CYP3A4 (1.00) | CYP3A4GRK2MEN1KMT2ATP53 | |
| Paroxetine SCHEMBL9398356 | 0.99 | CYP3A4 (1.00) | CYP3A4GRK2MEN1KMT2ATP53 | |
| Paroxetine SCHEMBL3854638 | 0.99 | CYP3A4 (1.00) | CYP3A4GRK2MEN1KMT2ATP53 | |
| Paroxetine SCHEMBL3461989 | 0.99 | CYP3A4 (0.98) | CYP3A4GRK2MEN1KMT2ATP53 | |
| Paroxetine SCHEMBL18937018 | 0.99 | CYP3A4 (0.98) | CYP3A4GRK2MEN1KMT2ATP53 | |
| Paroxetine SCHEMBL2847926 | 0.99 | CYP3A4 (1.00) | CYP3A4GRK2MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6657062-B1 | Chemical intermediates for paroxetine derivatives; formylation, resolution, reduction, salt formation, catalysis | RICHTER GEDEON VEGYESSETI GYAR RT. (HU) | 2003-12-02 | — | — | US | disclosed |
| EP-0923554-B1 | N-BENZYLPIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | RICHTER GEDEON VEGYESZET (HU) | 2002-01-09 | — | — | EP | disclosed |
| EP-0923554-A1 | N-BENZYLPIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998001424-A1 | N-BENZYLPIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 1998-01-15 | — | — | WO | disclosed |