Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 3/20 | 0.58 |
| ▸ | MGAM | O43451 | 3/20 | 0.58 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.58 |
| ▸ | PLA2G5 | P39877 | 3/20 | 0.58 |
| ▸ | PLA2G12A | Q9BZM1 | 3/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.47 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.47 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30273097 | 0.79 | PARP1 (0.51) | PLA2G10MGAMPLA2G2APLA2G5PLA2G12A | |
| SCHEMBL3337877 | 0.79 | PARP1 (0.51) | PLA2G10MGAMPLA2G2APLA2G5PLA2G12A | |
| SCHEMBL30381143 | 0.78 | DAO (0.49) | PLA2G10MGAMPLA2G2APLA2G5PLA2G12A | |
| SCHEMBL24099213 | 0.78 | DAO (0.49) | PLA2G10MGAMPLA2G2APLA2G5PLA2G12A | |
| SCHEMBL3341807 | 0.76 | PLA2G10 (0.56) | PLA2G10MGAMPLA2G2APLA2G5PLA2G12A | |
| SCHEMBL3338398 | 0.75 | PLA2G10 (0.51) | PLA2G10MGAMPLA2G2APLA2G5PLA2G12A | |
| SCHEMBL29673205 | 0.68 | PARP1 (1.00) | PARP1MAP4K4TAOK1PBKSLK | |
| SCHEMBL1133601 | 0.68 | PARP1 (1.00) | PARP1MAP4K4TAOK1PBKSLK | |
| SCHEMBL23869965 | 0.68 | CDC25B (0.72) | PLA2G10MGAMPLA2G2APLA2G5PLA2G12A | |
| SCHEMBL30273108 | 0.68 | ADORA3 (0.48) | PLA2G10MGAMPLA2G2APLA2G5PLA2G12A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152180-A1 | 4-oxo-4,5-dihydropyrrolo[1,2-A)quinoxaline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152180-A1 | 4-oxo-4,5-dihydropyrrolo[1,2-A)quinoxaline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP) | PARP1, PARP2, PARP4 | PLA2G10 4343/4885MGAM 4084/4885PLA2G2A 4022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.