Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | IDO1 | P14902 | 4/20 | 0.53 |
| ▸ | TDO2 | P48775 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TPMT | P51580 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | NQO2 | P16083 | 3/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29824959 | 0.80 | KDM4E (1.00) | KDM4EHPGDALDH1A1LMNAIDO1 | |
| SCHEMBL3602542 | 0.80 | KDM4E (1.00) | KDM4EHPGDALDH1A1LMNAIDO1 | |
| SCHEMBL30397196 | 0.78 | KDM4E (0.63) | KDM4EHPGDALDH1A1LMNAIDO1 | |
| SCHEMBL20505539 | 0.78 | KDM4E (0.63) | KDM4EHPGDALDH1A1LMNAIDO1 | |
| SCHEMBL2908763 | 0.77 | KDM4E (0.59) | KDM4EHPGDALDH1A1LMNAIDO1 | |
| SCHEMBL1771123 | 0.77 | HPGD (1.00) | KDM4EHPGDALDH1A1LMNAIDO1 | |
| SCHEMBL1145054 | 0.76 | HPGD (0.70) | KDM4EHPGDALDH1A1LMNAIDO1 | |
| SCHEMBL1144735 | 0.76 | KDM4E (0.79) | KDM4EHPGDALDH1A1LMNAIDO1 | |
| Hydrochloric Acid SCHEMBL3555727 | 0.76 | HPGD (0.97) | KDM4EHPGDALDH1A1LMNAIDO1 | |
| SCHEMBL24112536 | 0.76 | KDM4E (0.60) | KDM4EHPGDALDH1A1LMNAIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144779-A1 | Marine Alkalod Makaluvamines and Derivatives Thereof | THE UAB RESEARCH FOUNDATION (US) | 2010-06-10 | — | — | US | disclosed |
| WO-2008103483-A2 | MARINE ALKALOID MAKALUVAMINES AND DERIVATIVES THEREOF | THE UAB RESEARCH FOUNDATION (US) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144779-A1 | Marine Alkalod Makaluvamines and Derivatives Thereof | TOP2A, CHEK2, TOP2B | KDM4E 541/4885HPGD 1636/4885ALDH1A1 3137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.