Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 3/20 | 0.35 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44488 | 0.97 | — | — | |
| SCHEMBL5030994 | 0.94 | MAPT (0.40) | MAPTMAPK1PRKCAOR51E2MGLL | |
| SCHEMBL6009741 | 0.94 | MAPT (0.40) | MAPTMAPK1PRKCAOR51E2MGLL | |
| Alcohol SCHEMBL20504372 | 0.89 | MAPT (0.47) | MAPTMAPK1PRKCAOR51E2FAAH | |
| Oxirane SCHEMBL23581829 | 0.85 | MAPT (0.35) | MAPTMAPK1PRKCA | |
| SCHEMBL2231085 | 0.85 | PRKCA (0.35) | MAPTMAPK1PRKCAMGLLPRKCE | |
| Ether SCHEMBL1902737 | 0.83 | MAPT (0.42) | MAPTMAPK1PRKCAFAAHALDH1A1 | |
| Glutarate SCHEMBL7174556 | 0.83 | SLC22A6 (0.50) | MAPTMAPK1MGLLALDH1A1 | |
| SCHEMBL1686207 | 0.81 | MAPT (0.36) | MAPTMAPK1PRKCAOR51E2PRKCE | |
| SCHEMBL13534692 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148916-B1 | METHOD OF MAKING POLYGLYCEROL ESTERS | CRODA INT PLC (GB) | 2016-01-13 | — | — | EP | disclosed |
| US-8722814-B2 | Method of making polyglycerol esters | CRODA INTERNATIONAL PLC (GB) | 2014-05-13 | — | — | US | disclosed |
| US-20100144978-A1 | METHOD OF MAKING POLYGLYCEROL ESTERS | CRODA INTERNATIONAL PLC (GB) | 2010-06-10 | — | — | US | disclosed |
| EP-2148916-A1 | METHOD OF MAKING POLYGLYCEROL ESTERS | Croda International PLC (GB) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008142374-A1 | METHOD OF MAKING POLYGLYCEROL ESTERS | CRODA INTERNATIONAL PLC (GB) | 2008-11-27 | — | — | WO | disclosed |