Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DGKA | P23743 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904699 | 0.97 | — | — | |
| SCHEMBL2905861 | 0.97 | — | — | |
| SCHEMBL44489 | 0.97 | — | — | |
| SCHEMBL6009745 | 0.95 | LMNA (0.46) | LMNAKDM4EDUSP3MEN1KMT2A | |
| SCHEMBL5030996 | 0.95 | LMNA (0.46) | LMNAKDM4EDUSP3MEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL29173217 | 0.95 | LMNA (0.46) | LMNAKDM4EDUSP3MEN1KMT2A | |
| SCHEMBL27990517 | 0.93 | LMNA (0.44) | LMNAKDM4EDUSP3MEN1KMT2A | |
| SCHEMBL8033641 | 0.93 | LMNA (0.44) | LMNAKDM4EDUSP3MEN1KMT2A | |
| Formaldehyde SCHEMBL27893956 | 0.93 | LMNA (0.44) | LMNAKDM4EDUSP3MEN1KMT2A | |
| Acetone SCHEMBL2900783 | 0.91 | LMNA (0.47) | LMNAKDM4EDUSP3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148916-B1 | METHOD OF MAKING POLYGLYCEROL ESTERS | CRODA INT PLC (GB) | 2016-01-13 | — | — | EP | disclosed |
| US-8722814-B2 | Method of making polyglycerol esters | CRODA INTERNATIONAL PLC (GB) | 2014-05-13 | — | — | US | disclosed |
| US-20100144978-A1 | METHOD OF MAKING POLYGLYCEROL ESTERS | CRODA INTERNATIONAL PLC (GB) | 2010-06-10 | — | — | US | disclosed |
| EP-2148916-A1 | METHOD OF MAKING POLYGLYCEROL ESTERS | Croda International PLC (GB) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008142374-A1 | METHOD OF MAKING POLYGLYCEROL ESTERS | CRODA INTERNATIONAL PLC (GB) | 2008-11-27 | — | — | WO | disclosed |