Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.68 |
| ▸ | INSR | P06213 | 1/20 | 0.68 |
| ▸ | IGF1R | P08069 | 1/20 | 0.68 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.68 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.68 |
| ▸ | CCNK | O75909 | 2/20 | 0.68 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.68 |
| ▸ | CDK2 | P24941 | 2/20 | 0.68 |
| ▸ | CCND3 | P30281 | 2/20 | 0.68 |
| ▸ | CDK9 | P50750 | 2/20 | 0.68 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.68 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.68 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.68 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.67 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 7/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.63 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13320273 | 0.90 | PKMYT1 (0.56) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL3337236 | 0.90 | MAPK8 (0.66) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL13300743 | 0.88 | MAPK8 (0.71) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL13300734 | 0.88 | PTK2 (0.64) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL13300731 | 0.88 | MAPK8 (0.64) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL13300733 | 0.88 | PKMYT1 (0.68) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL13300667 | 0.88 | PKMYT1 (0.70) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL13300727 | 0.87 | MAPK8 (0.62) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL13300736 | 0.87 | MAPK9 (0.69) | PKMYT1INSRIGF1RPTK2PTK2B | |
| SCHEMBL13300729 | 0.86 | PKMYT1 (0.60) | PKMYT1INSRIGF1RPTK2PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144732-A1 | PYRIMIDINE KINASE INHIBITORS | GENENTECH, INC. | 2010-06-10 | — | — | US | disclosed |
| US-20100144732-A1 | PYRIMIDINE KINASE INHIBITORS | GENENTECH, INC. | 2010-06-10 | — | — | US | disclosed |
| EP-2099771-A1 | PYRIMIDINE KINASE INHIBITORS | Genentech, Inc. (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008079719-A1 | PYRIMIDINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008079719-A1 | PYRIMIDINE KINASE INHIBITORS | GENENTECH, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144732-A1 | PYRIMIDINE KINASE INHIBITORS | DTYMK, DCK, TYMP | PKMYT1 463/4885INSR 1809/4885IGF1R 1550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.