Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 5/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 3/20 | 0.36 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3334883 | 0.99 | MAPT (0.39) | MAPTS1PR1NAAAGAAHTT | |
| SCHEMBL3338292 | 0.89 | TACR1 (0.41) | MAPTS1PR1GAATACR1S1PR4 | |
| SCHEMBL3338015 | 0.89 | MAPT (0.49) | MAPTS1PR1S1PR4 | |
| Hydrochloric Acid SCHEMBL3339470 | 0.88 | TACR1 (0.40) | MAPTS1PR1GAATACR1S1PR4 | |
| SCHEMBL3342606 | 0.88 | PPARG (0.33) | MAPTGAAHTT | |
| Hydrochloric Acid SCHEMBL3336871 | 0.88 | MAPT (0.48) | MAPTS1PR1S1PR4 | |
| SCHEMBL3336953 | 0.87 | SMN1; SMN2 (0.42) | MAPTS1PR1NAAATRPV1 | |
| SCHEMBL27782059 | 0.87 | SMN1; SMN2 (0.42) | MAPTS1PR1NAAATRPV1 | |
| Hydrochloric Acid SCHEMBL3336966 | 0.87 | PPARG (0.32) | MAPTGAAHTT | |
| Hydrochloric Acid SCHEMBL3336446 | 0.86 | SMN1; SMN2 (0.41) | MAPTS1PR1NAAAKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2202227-B1 | NOVEL HISTIDINE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2013-11-20 | — | — | EP | disclosed |
| US-8324261-B2 | Histidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2012-12-04 | — | — | US | disclosed |
| EP-2202227-A1 | NOVEL HISTIDINE DERIVATIVE | Nippon Zoki Pharmaceutical Co., Ltd. (JP) | 2010-06-30 | — | — | EP | disclosed |
| US-20100152459-A1 | NOVEL HISTIDINE DERIVATIVES | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152459-A1 | NOVEL HISTIDINE DERIVATIVES | HRH4, HNMT, HRH3 | MAPT 3851/4885S1PR1 2270/4885NAAA 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.