Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.50 |
| ▸ | AURKA | O14965 | 5/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13431475 | 0.88 | RAB9A (0.60) | RAB9AHTTSMN1; SMN2CLK4LMNA | |
| SCHEMBL3338968 | 0.88 | RAB9A (0.49) | RAB9AHTTSMN1; SMN2AURKAAURKB | |
| SCHEMBL3339831 | 0.86 | HTT (0.51) | RAB9AHTTSMN1; SMN2CLK4CDK8 | |
| SCHEMBL3339949 | 0.85 | RAB9A (0.52) | RAB9AHTTSMN1; SMN2CDK8LMNA | |
| SCHEMBL3343049 | 0.85 | RAB9A (0.60) | RAB9AHTTSMN1; SMN2CDK8LMNA | |
| SCHEMBL3340533 | 0.84 | RAB9A (0.49) | RAB9AHTTSMN1; SMN2AURKACDK8 | |
| SCHEMBL3345323 | 0.84 | TP53 (0.60) | RAB9AHTTSMN1; SMN2CLK4AURKA | |
| SCHEMBL3340270 | 0.83 | RAB9A (0.52) | RAB9AHTTSMN1; SMN2CDK8RPS6KB1 | |
| SCHEMBL3338893 | 0.81 | EGFR (0.51) | RAB9AHTTSMN1; SMN2CDK8FGFR1 | |
| SCHEMBL3339730 | 0.81 | HTT (0.48) | RAB9AHTTSMN1; SMN2AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063047-A1 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063047-A1 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH2, HRH3 | RAB9A 2578/4885HTT 383/4885SMN1; SMN2 4740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.