Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3341379 | 0.89 | PDE5A (0.57) | SMN1; SMN2PDE5AALDH1A1MEN1KMT2A | |
| SCHEMBL5117409 | 0.83 | ESR1 (0.53) | HTTPDE5AALDH1A1MAPTNPSR1 | |
| SCHEMBL7617647 | 0.81 | PDE5A (0.52) | SMN1; SMN2HTTRAB9APDE5AALDH1A1 | |
| SCHEMBL3385119 | 0.81 | LMNA (0.49) | SMN1; SMN2HTTRAB9AALDH1A1MAPT | |
| SCHEMBL13431476 | 0.81 | SMN1; SMN2 (0.65) | SMN1; SMN2HTTRAB9AALDH1A1MAPT | |
| SCHEMBL5122824 | 0.80 | PRKCI (0.46) | PDE5A | |
| SCHEMBL5119891 | 0.79 | METAP1 (0.44) | SMN1; SMN2HTTRAB9APDE5AALDH1A1 | |
| SCHEMBL13431477 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2HTTRAB9AALDH1A1MAPT | |
| SCHEMBL5124266 | 0.79 | BCDIN3D (0.42) | HTTPDE5AALDH1A1MAPTNPSR1 | |
| SCHEMBL5128338 | 0.79 | BCDIN3D (0.39) | SMN1; SMN2HTTRAB9APDE5AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063047-A1 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063047-A1 | AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH2, HRH3 | SMN1; SMN2 4740/4885HTT 383/4885RAB9A 2578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.