Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.50 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodobenzene SCHEMBL2485086 | 1.00 | CES1 (0.50) | CES1TPMTCPA1CYP1A2TRPV1 | |
| Iodobenzene SCHEMBL2237441 | 1.00 | CES1 (0.50) | CES1TPMTCPA1CYP1A2TRPV1 | |
| Iodobenzene SCHEMBL15140156 | 0.93 | CES1 (0.45) | CES1TPMTCPA1CYP1A2TRPV1 | |
| Iodobenzene SCHEMBL27524285 | 0.88 | CES1 (0.54) | CES1TPMTCPA1TRPV1PTPN1 | |
| Iodobenzene SCHEMBL28043258 | 0.88 | CES1 (0.41) | CES1TPMTCPA1TRPV1FAAH | |
| Iodobenzene SCHEMBL28291735 | 0.88 | CES1 (0.41) | CES1TPMTCPA1CYP1A2TRPV1 | |
| Trifluoroacetic Acid SCHEMBL28511407 | 0.81 | TPMT (0.44) | CES1TPMTTRPV1 | |
| Pivalate SCHEMBL28120842 | 0.80 | TPMT (0.42) | TPMTCYP1A2HDAC6 | |
| Pivalate SCHEMBL5330607 | 0.80 | TPMT (0.42) | TPMTCYP1A2HDAC6 | |
| Trifluoroacetic Acid SCHEMBL8845061 | 0.79 | TPMT (0.43) | CES1TPMTTRPV1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 489 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118125939-A | Azido-containing asymmetric o-diamine compound and synthesis method thereof | 湘潭大学 | 2024-06-04 | — | — | CN | claimed |
| CN-118084850-A | Synthesis method of 1-oxo subunit dibenzo [ a, kl ] xanthene-13 c (1H) -carbonitrile | 兰州石化职业技术大学 | 2024-05-28 | — | — | CN | claimed |
| CN-117924369-A | Phosphite group-containing carbazole polymerization inhibitor, preparation method and application thereof | 万华化学集团股份有限公司 | 2024-04-26 | — | — | CN | claimed |
| CN-115583919-B | Preparation method of 6-oxyalkyl 1,2, 4-triazine-3, 5 (2H, 4H) -diketone derivative | 河北工业大学 | 2024-04-19 | — | — | CN | claimed |
| CN-116715698-A | Preparation method of 6-phosphoryl 1,2, 4-triazine-3, 5 (2H, 4H) -diketone derivative | 河北工业大学 | 2023-09-08 | — | — | CN | claimed |
| CN-115583919-A | Preparation method of 6-oxyalkyl 1,2,4-triazine-3,5 (2H, 4H) -diketone derivative | 河北工业大学 | 2023-01-10 | — | — | CN | claimed |
| CN-115521257-A | Alpha-substituted azolidone derivative and synthesis method thereof | 浙江树人学院 | 2022-12-27 | — | — | CN | claimed |
| CN-114685421-A | Galanthamine intermediate compound | 鲁南制药集团股份有限公司 | 2022-07-01 | — | — | CN | claimed |
| CN-112812068-B | Alpha-amino alkylation method for C3 site of quinoxalinone | 浙江工业大学 | 2022-04-08 | — | — | CN | claimed |
| CN-113135911-B | Method for preparing pyridotriazolone compounds by flow chemistry | 浙江工业大学 | 2022-03-18 | — | — | CN | claimed |
| US-20050250759-A1 | Spirolactams and their synthesis | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2005-11-10 | — | — | US | claimed |
| WO-2005058910-A1 | THE METHOD OF MANUFACTURING OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN | PLIVA-LACHEMA A.S. (CZ) | 2005-06-30 | — | — | WO | claimed |
| EP-1487859-A2 | PROCESS TO PREPARE EPLERENONE | PHARMACIA & UPJOHN COMPANY (US) | 2004-12-22 | — | — | EP | claimed |
| US-20030232981-A1 | Contacting a Delta 3,5-3-enol ether of formula (alkyl enol ether) with a hydride abstractor and an alcohol | PHARMACIA & UPJOHN COMPANY | 2003-12-18 | — | — | US | claimed |
| WO-2003082895-A2 | PROCESS TO PREPARE EPLERENONE | PHARMACIA & UPJOHN COMPANY (US) | 2003-10-09 | — | — | WO | claimed |
| EP-0547165-B1 | Process for the Preparation of Water-Soluble Camptothecin Analogues, as well as the compounds 10-Hydroxy-11-C(1-6)-alkoxycamptothecin | SMITHKLINE BEECHAM CORP (US) | 1999-11-10 | — | — | EP | claimed |
| US-5734056-A | Process for the preparation of certain 9-substituted camptothecins | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-31 | — | — | US | claimed |
| EP-0547165-A4 | — | — | 1994-03-30 | — | — | EP | claimed |
| EP-0547165-A1 | WATER SOLUBLE CAMPTOTHECIN ANALOGUES, PROCESSES AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1993-06-23 | — | — | EP | claimed |
| WO-1992005785-A1 | WATER SOLUBLE CAMPTOTHECIN ANALOGUES, PROCESSES AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-04-16 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250759-A1 | Spirolactams and their synthesis | VKORC1, DHPS, SRI | CES1 3020/4885TPMT 417/4885CPA1 3859/4885 |
| US-20030232981-A1 | Contacting a Delta 3,5-3-enol ether of formula (alkyl enol ether) with a hydride abstractor and an alcohol | NR3C2, HSD3B2, HSD11B2 | CES1 698/4885TPMT 4268/4885CPA1 3832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.