Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 8/20 | 0.47 |
| ▸ | RBP4 | P02753 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21609778 | 0.92 | NOTUM (0.57) | NOTUMPDK2RBP4SMN1; SMN2TSHR | |
| SCHEMBL7823276 | 0.88 | PDK2 (0.57) | NOTUMPDK2RBP4TSHRSCN9A | |
| SCHEMBL21818278 | 0.88 | PPARG (0.46) | NOTUMPDK2SMN1; SMN2PPARGPPARA | |
| SCHEMBL7947891 | 0.85 | BACE1 (0.48) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL28824318 | 0.80 | SCN9A (0.48) | PDK2ALDH1A1HPGDPPARGPPARA | |
| SCHEMBL536257 | 0.79 | NOTUM (0.55) | NOTUMPDK2RBP4SMN1; SMN2TSHR | |
| SCHEMBL2776641 | 0.78 | NOTUM (0.54) | NOTUMPDK2RBP4SMN1; SMN2ALDH1A1 | |
| SCHEMBL3903631 | 0.78 | EGFR (0.57) | NOTUMPDK2TSHRLDHA | |
| SCHEMBL29630556 | 0.78 | ALDH1A1 (0.51) | ALDH1A1HPGDPPARGPPARAFFAR4 | |
| SCHEMBL5934523 | 0.77 | PDK2 (0.49) | PDK2SMN1; SMN2TSHRPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042030-A1 | ASPARTYL PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010042030-A1 | ASPARTYL PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2010-04-15 | — | — | WO | disclosed |
| WO-2008119773-A1 | AMIDE DERIVATIVES AS INHIBITORS OF ASPARTYL PROTEASES | MEDIVIR AB (SE) | 2008-10-09 | — | — | WO | disclosed |
| WO-2008119773-A1 | AMIDE DERIVATIVES AS INHIBITORS OF ASPARTYL PROTEASES | MEDIVIR AB (SE) | 2008-10-09 | — | — | WO | disclosed |