Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PDE9A | O76083 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3337470 | 0.84 | PARP1 (0.48) | PARP1ALDH1A1KMT2AKDM4EPDE9A | |
| SCHEMBL3339022 | 0.80 | PARP1 (0.54) | PARP1ALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL3339450 | 0.80 | PARP1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL28895087 | 0.77 | PARP1 (0.46) | PARP1ALDH1A1KMT2AAURKAKDM4E | |
| SCHEMBL3336666 | 0.76 | PARP1 (0.66) | PARP1ALDH1A1KMT2A | |
| SCHEMBL3341807 | 0.76 | PLA2G10 (0.56) | GRIA1GRIA2GRIA3GRIA4GRIN2D | |
| SCHEMBL3784199 | 0.71 | PARP1 (0.68) | PARP1ALDH1A1KMT2AAURKAKDM4E | |
| SCHEMBL21642461 | 0.71 | GRIA2 (0.51) | GRIA1GRIA2GRIA3GRIA4PARP1 | |
| SCHEMBL29203506 | 0.70 | PARP1 (0.46) | PARP1ALDH1A1KMT2AAURKAKDM4E | |
| SCHEMBL3590864 | 0.70 | PDE9A (0.49) | GRIA1GRIA2GRIA3GRIA4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152180-A1 | 4-oxo-4,5-dihydropyrrolo[1,2-A)quinoxaline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152180-A1 | 4-oxo-4,5-dihydropyrrolo[1,2-A)quinoxaline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP) | PARP1, PARP2, PARP4 | GRIA1 3117/4885GRIA2 3547/4885GRIA3 3120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.