Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 7/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340593 | 0.92 | XDH (0.52) | XDH | |
| SCHEMBL3338671 | 0.79 | XDH (0.44) | XDH | |
| SCHEMBL3340011 | 0.76 | XDH (0.47) | XDH | |
| SCHEMBL7645245 | 0.75 | XDH (0.47) | XDH | |
| SCHEMBL386915 | 0.72 | KDM4E (0.61) | — | |
| SCHEMBL14023022 | 0.72 | PIM1 (0.55) | XDH | |
| SCHEMBL3341820 | 0.71 | CDC7 (0.43) | XDH | |
| SCHEMBL386224 | 0.71 | PIM1 (0.67) | XDH | |
| SCHEMBL3340437 | 0.70 | XDH (0.44) | XDH | |
| SCHEMBL3342615 | 0.69 | TP53 (0.43) | XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074114-B1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS INC (US) | 2013-03-06 | — | — | EP | disclosed |
| US-8324231-B2 | Pyrimidinones as casein kinase II (CK2) modulators | EXELIXIS, INC. (US) | 2012-12-04 | — | — | US | disclosed |
| CN-102317281-A | Pyrimidinones as Casein Hormone II (CK2) Modulators | EXELIXIS INC | 2012-01-11 | — | — | CN | disclosed |
| US-20100144770-A1 | Pyrimidinones as Casein Kinase II (CK2) Modulators | EXELIXIS, INC. (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144770-A1 | Pyrimidinones as Casein Kinase II (CK2) Modulators | CSNK2A1, CSNK2A2, CSNK1A1 | XDH 283/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.