Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | DAO | P14920 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2284169 | 0.84 | TAAR1 (0.55) | MEN1KMT2ASMN1; SMN2TAAR1DAO | |
| SCHEMBL2483213 | 0.76 | PDE3B (0.42) | MEN1KMT2ASMN1; SMN2TAAR1DAO | |
| SCHEMBL4016016 | 0.76 | PDE3B (0.51) | MEN1KMT2ASMN1; SMN2TAAR1GSK3B | |
| SCHEMBL3639622 | 0.73 | GPR84 (0.51) | MEN1KMT2ASMN1; SMN2TAAR1GSK3B | |
| SCHEMBL570036 | 0.72 | TAAR1 (0.69) | SMN1; SMN2TAAR1DAOPDE10ANPC1 | |
| SCHEMBL791861 | 0.71 | GPR84 (0.54) | KMT2AGSK3BGPR84 | |
| SCHEMBL12927964 | 0.71 | DAO (0.49) | MEN1KMT2ASMN1; SMN2TAAR1DAO | |
| SCHEMBL14486412 | 0.71 | DAO (1.00) | DAOPDE10AMMP2RNASEH1MMP9 | |
| SCHEMBL10927286 | 0.71 | — | — | |
| SCHEMBL14639314 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010039922-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |