Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 9/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3449014 | 0.87 | SYK (0.47) | RIPK2ACVR1ABL1JAK3JAK1 | |
| SCHEMBL13348282 | 0.83 | CSNK2A1 (0.49) | ABL1BCRAURKAAURKBJAK2 | |
| SCHEMBL3448524 | 0.81 | SYK (0.45) | RIPK2ACVR1JAK3SYKJAK2 | |
| SCHEMBL3448872 | 0.80 | SYK (0.44) | RIPK2ACVR1JAK3JAK1SYK | |
| SCHEMBL3451567 | 0.79 | EGFR (0.44) | RIPK2ACVR1ABL1JAK3JAK1 | |
| SCHEMBL3449534 | 0.78 | RIPK2 (0.45) | RIPK2ACVR1ABL1JAK3JAK1 | |
| SCHEMBL3449538 | 0.78 | RIPK2 (0.45) | RIPK2ACVR1ABL1JAK3JAK1 | |
| SCHEMBL13421189 | 0.78 | RIPK2 (0.39) | RIPK2ACVR1JAK3JAK1NOD2 | |
| SCHEMBL13421190 | 0.78 | RIPK2 (0.39) | RIPK2ACVR1JAK3JAK1NOD2 | |
| SCHEMBL3451569 | 0.76 | RIPK2 (0.43) | RIPK2ACVR1ABL1JAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |