Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 9/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3448178 | 0.88 | PTK2 (0.39) | RIPK2ACVR1SYKJAK3JAK1 | |
| SCHEMBL3452880 | 0.88 | PTGS2 (0.38) | JAK3EGFRCDK9PTK2PTGS2 | |
| SCHEMBL3449534 | 0.85 | RIPK2 (0.45) | RIPK2ACVR1SYKJAK3JAK1 | |
| SCHEMBL3449538 | 0.85 | RIPK2 (0.45) | RIPK2ACVR1SYKJAK3JAK1 | |
| SCHEMBL3449929 | 0.82 | SYK (0.43) | RIPK2ACVR1SYKJAK3NOD2 | |
| SCHEMBL3451566 | 0.82 | RIPK2 (0.41) | RIPK2ACVR1SYKJAK3JAK1 | |
| SCHEMBL3451567 | 0.82 | EGFR (0.44) | RIPK2ACVR1SYKJAK3JAK1 | |
| SCHEMBL3451327 | 0.82 | SYK (0.42) | RIPK2ACVR1SYKJAK3JAK1 | |
| SCHEMBL3344573 | 0.76 | RIPK2 (0.47) | RIPK2ACVR1SYKJAK3JAK1 | |
| SCHEMBL3449014 | 0.74 | SYK (0.47) | RIPK2ACVR1SYKJAK3JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | RIPK2 4693/4885ACVR1 4662/4885SYK 804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.