Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL202937 | 0.80 | KDM4E (0.40) | PARP1KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL1046464 | 0.76 | CDK4 (0.44) | PARP1KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL16748186 | 0.74 | TYRO3 (0.42) | KDM4EPDE3BPDE3APDE2AHTR1A | |
| SCHEMBL30846772 | 0.73 | PARP1 (0.42) | PARP1KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL2326520 | 0.72 | PRMT5 (0.41) | PARP1KDM4EADORA3ADORA2AADORA1 | |
| SCHEMBL660137 | 0.71 | MAPT (0.50) | PARP1KDM4EDAOATAD2CDK4 | |
| SCHEMBL11623832 | 0.71 | PARP1 (0.41) | PARP1KDM4EGABRA1GABRG2GABRB3 | |
| SCHEMBL66937 | 0.69 | PARP1 (0.58) | PARP1KDM4EADORA3ADORA2AADORA1 | |
| SCHEMBL2326516 | 0.69 | ADORA3 (0.45) | PARP1GABRA1GABRG2GABRB3GABRA5 | |
| Fumaric Acid SCHEMBL18894354 | 0.67 | MAPT (0.41) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038165-A1 | IMIDAZO[1,5]NAPHTHYRIDINE COMPOUNDS, THEIR PHARMACEUTICAL USE AND COMPOSITIONS | PFIZER INC. (US) | 2010-04-08 | — | — | WO | disclosed |