Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.83 |
| ▸ | CDK2 | P24941 | 3/20 | 0.66 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314176 | 0.91 | IGF1R (1.00) | IGF1RCDK2EGFRKCNH2 | |
| SCHEMBL3352606 | 0.91 | IGF1R (0.79) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL2347439 | 0.90 | IGF1R (0.80) | IGF1RCDK2EGFRKCNH2TNK2 | |
| SCHEMBL2345579 | 0.88 | IGF1R (0.84) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL2347583 | 0.87 | IGF1R (0.76) | IGF1RCDK2EGFRKCNH2TNK2 | |
| SCHEMBL13362109 | 0.86 | IGF1R (0.75) | IGF1RCDK2EGFRKCNH2 | |
| SCHEMBL3313873 | 0.86 | IGF1R (0.74) | IGF1RCDK2EGFRKCNH2 | |
| SCHEMBL3314030 | 0.85 | IGF1R (0.85) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL3345531 | 0.85 | IGF1R (0.66) | IGF1RCDK2EGFRKCNH2TNK2 | |
| SCHEMBL3315412 | 0.85 | IGF1R (0.72) | IGF1RCDK2EGFRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | claimed |
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |