Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 13/20 | 0.66 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2354282 | 0.91 | IGF1R (0.74) | IGF1RCDK2EGFRKCNH2ALK | |
| SCHEMBL2350163 | 0.87 | IGF1R (0.65) | IGF1RCDK2EGFRKCNH2 | |
| SCHEMBL2352771 | 0.85 | IGF1R (0.60) | IGF1RCDK2EGFRKCNH2 | |
| SCHEMBL2348737 | 0.85 | IGF1R (0.62) | IGF1RCDK2EGFRKCNH2ALK | |
| SCHEMBL2345514 | 0.85 | IGF1R (0.60) | IGF1RCDK2EGFRKCNH2 | |
| SCHEMBL3344728 | 0.85 | IGF1R (0.83) | IGF1RCDK2EGFRKCNH2INSR | |
| SCHEMBL3313052 | 0.85 | IGF1R (0.67) | IGF1RCDK2EGFRKCNH2ALK | |
| SCHEMBL2347443 | 0.82 | IGF1R (0.69) | IGF1RCDK2EGFRKCNH2ALK | |
| SCHEMBL3316462 | 0.82 | IGF1R (0.62) | IGF1RCDK2EGFRKCNH2ALK | |
| SCHEMBL3311579 | 0.82 | IGF1R (0.62) | IGF1RCDK2EGFRKCNH2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |