Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12113978 | 0.89 | KCNA3 (0.42) | TOP2A | |
| SCHEMBL3328189 | 0.84 | TOP2A (0.40) | TOP2APOLBMCHR1CCR1CARM1 | |
| SCHEMBL3323992 | 0.84 | TOP2A (0.40) | TOP2APOLBMCHR1CCR1CARM1 | |
| SCHEMBL1312328 | 0.84 | TOP2A (0.35) | TOP2A | |
| Hydrochloric Acid SCHEMBL1312760 | 0.83 | TOP2A (0.35) | TOP2A | |
| SCHEMBL1312958 | 0.82 | TOP2A (0.33) | TOP2A | |
| SCHEMBL3327648 | 0.80 | TOP2A (0.53) | TOP2APOLBKCNH2CCR1 | |
| SCHEMBL3324741 | 0.78 | TOP2A (0.57) | TOP2APOLBCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1313181 | 0.76 | TOP2A (0.61) | TOP2AKCNH2 | |
| SCHEMBL3730946 | 0.75 | CCR1 (0.35) | TOP2APOLBMCHR1CCR1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043714-A1 | TRICYCLIC NITROGEN COMPOUNDS USED AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |