Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 18/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3342908 | 0.90 | CASR (0.56) | CASRNR1I2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3344719 | 0.88 | CASR (0.63) | CASRNR1I2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3386803 | 0.87 | CASR (0.55) | CASRNR1I2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3345007 | 0.87 | CASR (0.80) | CASRNR1I2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3417713 | 0.87 | CASR (0.61) | CASRNR1I2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3344800 | 0.87 | CASR (0.74) | CASRNR1I2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3383643 | 0.86 | CASR (0.60) | CASRNR1I2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3416178 | 0.86 | CASR (0.60) | CASRNR1I2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3387700 | 0.86 | CASR (0.64) | CASRNR1I2ALDH1A1LMNACYP1A2 | |
| SCHEMBL3420596 | 0.86 | CASR (0.61) | CASRNR1I2ALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065383-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-06-10 | — | — | WO | disclosed |
| WO-2010039922-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-04-08 | — | — | WO | disclosed |