Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 14/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384788 | 0.90 | NR1I2 (0.54) | CASRNR1I2ALDH1A1TSHRLMNA | |
| SCHEMBL3385555 | 0.89 | CASR (0.59) | CASRNR1I2ALDH1A1TSHRLMNA | |
| SCHEMBL3416178 | 0.88 | CASR (0.60) | CASRNR1I2ALDH1A1TSHRLMNA | |
| SCHEMBL3387919 | 0.87 | CASR (0.75) | CASRNR1I2ALDH1A1TSHR | |
| SCHEMBL3420596 | 0.87 | CASR (0.61) | CASRNR1I2ALDH1A1TSHRLMNA | |
| SCHEMBL3417713 | 0.87 | CASR (0.61) | CASRNR1I2ALDH1A1TSHRLMNA | |
| SCHEMBL3345007 | 0.87 | CASR (0.80) | CASRNR1I2ALDH1A1TSHRLMNA | |
| SCHEMBL3345000 | 0.86 | CASR (0.60) | CASRNR1I2ALDH1A1TSHRLMNA | |
| SCHEMBL3416649 | 0.86 | CASR (0.59) | CASRNR1I2ALDH1A1TSHRLMNA | |
| SCHEMBL3387700 | 0.85 | CASR (0.64) | CASRNR1I2ALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010065383-A1 | CALCILYTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-06-10 | — | — | WO | disclosed |