Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Desvenlafaxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 9/20 | 0.97 |
| ▸ | SLC6A4 known ✓ | P31645 | 9/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | CNR1 | P21554 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | HRH1 | P35367 | 1/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desvenlafaxine SCHEMBL4306707 | 0.98 | SLC6A2 (0.97) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL4306704 | 0.98 | SLC6A2 (0.97) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| SCHEMBL10772550 | 0.98 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL34864 | 0.98 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL34863 | 0.98 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL3277527 | 0.98 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL2053955 | 0.97 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Hydrochloric Acid SCHEMBL10491682 | 0.97 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL623709 | 0.97 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Hydrochloric Acid SCHEMBL10772551 | 0.97 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3677254-B1 | SOLID ORAL PHARMACEUTICAL COMPOSITIONS OF DESVENLAFAXINE | SANOVEL ILAC SANAYI VE TICARET AS (TR) | 2023-10-25 | — | — | EP | claimed |
| EP-2252573-A2 | NEW POLYMORPH AND AMORPHOUS FORMS OF DESVENLAFAXINE FUMARATE | Egis Gyógyszergyár Nyilvánosan Müködö (HU) | 2010-11-24 | — | — | EP | disclosed |
| EP-2252573-A2 | NEW POLYMORPH AND AMORPHOUS FORMS OF DESVENLAFAXINE FUMARATE | Egis Gyógyszergyár Nyilvánosan Müködö (HU) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009101458-A3 | NEW POLYMORPH AND AMORPHOUS FORMS OF DESVENLAFAXINE FUMARATE | EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MŰKÖDŐ (HU) | 2010-04-08 | — | — | WO | disclosed |
| WO-2009101458-A2 | NEW POLYMORPH AND AMORPHOUS FORMS OF DESVENLAFAXINE FUMARATE | EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MŰKÖDŐ (HU) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009101458-A2 | NEW POLYMORPH AND AMORPHOUS FORMS OF DESVENLAFAXINE FUMARATE | EGIS GYÓGYSZERGYÁR NYILVÁNOSAN MŰKÖDŐ (HU) | 2009-08-20 | — | — | WO | disclosed |