Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Desvenlafaxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 9/20 | 0.97 |
| ▸ | SLC6A4 known ✓ | P31645 | 9/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.94 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.94 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | CNR1 | P21554 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | HRH1 | P35367 | 1/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Desvenlafaxine SCHEMBL4306707 | 1.00 | SLC6A2 (0.97) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL623709 | 0.98 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL2053955 | 0.98 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Hydrochloric Acid SCHEMBL10491682 | 0.98 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL3345158 | 0.98 | SLC6A2 (0.97) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Hydrochloric Acid SCHEMBL10772551 | 0.98 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL34864 | 0.97 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL3277527 | 0.97 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| Desvenlafaxine SCHEMBL34863 | 0.97 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA | |
| SCHEMBL10772550 | 0.97 | SLC6A2 (1.00) | SLC6A2SLC6A4SLC6A3OPRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160355457-A1 | Solid Forms Comprising(-)-O-Desmethylvenlafaxine And Uses Thereof | SUNOVION PHARMACEUTICALS INC. | 2016-12-08 | — | — | US | disclosed |
| EP-2114863-B1 | SOLID FORMS COMPRISING (-)-O-DESMETHYLVENLAFAXINE AND USES THEREOF | SEPRACOR INC (US) | 2016-10-05 | — | — | EP | disclosed |
| EP-2500337-A2 | Solid form comprising (-) o-desmethylvenlafaxine and uses thereof | Sepracor Inc. (US) | 2012-09-19 | — | — | EP | disclosed |
| EP-2114863-A2 | SOLID FORMS COMPRISING (-) O-DESMETHYLVENLAFAXINE AND USES THEREOF | Sepracor Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| US-20090005457-A1 | Solid forms comprising (-)-O-desmethylvenlafaxine and uses thereof | SUNOVION PHARMACEUTICALS INC. | 2009-01-01 | — | — | US | disclosed |
| WO-2008103461-A2 | SOLID FORMS COMPRISING (-) O-DESMETHYLVENLAFAXINE AND USES THEREOF | SEPRACOR INC. (US) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160355457-A1 | Solid Forms Comprising(-)-O-Desmethylvenlafaxine And Uses Thereof | COMT, SLC6A3, SLC6A2 | SLC6A2 3/4885SLC6A4 4/4885SLC6A3 2/4885 |
| US-20090005457-A1 | Solid forms comprising (-)-O-desmethylvenlafaxine and uses thereof | COMT, SLC6A3, SLC6A2 | SLC6A2 3/4885SLC6A4 4/4885SLC6A3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.