SCHEMBL3345286

SCHEMBL3345286

CC(C)C[C@H](NCCCOc1ccc(I)cc1)C(=O)OC1CCCC1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 4/20 0.49
NPR3 P17342 1/20 0.43
HRH3 Q9Y5N1 3/20 0.42
ALDH1A1 P00352 4/20 0.42
MAPK13 O15264 1/20 0.41
MAPK12 P53778 1/20 0.41
MAPK11 Q15759 1/20 0.41
KDM4E B2RXH2 4/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
MMP2 P08253 2/20 0.40
MMP9 P14780 2/20 0.40
ANPEP P15144 2/20 0.40
LTA4H P09960 1/20 0.40
LAP3 P28838 1/20 0.40
NPEPPS P55786 1/20 0.40
ERAP2 Q6P179 1/20 0.40
ERAP1 Q9NZ08 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
TAS1R3 Q7RTX0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3345291 1.00 MAPK14 (0.49) MAPK14NPR3HRH3ALDH1A1MAPK13
SCHEMBL2280784 0.89 MAPK14 (0.49) MAPK14NPR3HRH3ALDH1A1MAPK13
SCHEMBL2280787 0.89 MAPK14 (0.49) MAPK14NPR3HRH3ALDH1A1MAPK13
SCHEMBL3345202 0.88 MAPK14 (0.48) MAPK14NPR3HRH3ALDH1A1MAPK13
SCHEMBL3345198 0.88 MAPK14 (0.48) MAPK14NPR3HRH3ALDH1A1MAPK13
SCHEMBL2278135 0.85 MAPK14 (0.53) MAPK14NPR3HRH3ALDH1A1MAPK13
SCHEMBL2278139 0.85 MAPK14 (0.53) MAPK14NPR3HRH3ALDH1A1MAPK13
SCHEMBL1411131 0.83 TAS1R3 (0.45) MAPK14KMT2AMMP2MMP9ANPEP
SCHEMBL1411128 0.83 TAS1R3 (0.45) MAPK14KMT2AMMP2MMP9ANPEP
SCHEMBL1411125 0.83 TAS1R3 (0.45) MAPK14KMT2AMMP2MMP9ANPEP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010043865-A1 INHIBITORS OF HSP90 CHROMA THERAPEUTICS LTD (GB) 2010-04-22 WO disclosed