Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.51 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.50 |
| ▸ | GRK5 | P34947 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1751711 | 0.87 | RORC (0.64) | RORCSIGMAR1S1PR5S1PR1 | |
| SCHEMBL12303485 | 0.87 | RORC (0.64) | RORCSIGMAR1S1PR5S1PR1 | |
| SCHEMBL1752417 | 0.87 | RORC (0.64) | RORCSIGMAR1S1PR5S1PR1 | |
| SCHEMBL419234 | 0.87 | RORC (0.64) | RORCSIGMAR1S1PR5S1PR1 | |
| SCHEMBL1752470 | 0.87 | RORC (0.64) | RORCSIGMAR1S1PR5S1PR1 | |
| SCHEMBL14371541 | 0.87 | RORC (0.64) | RORCSIGMAR1S1PR5S1PR1 | |
| SCHEMBL8484105 | 0.87 | RORC (0.64) | RORCSIGMAR1S1PR5S1PR1 | |
| SCHEMBL23923989 | 0.86 | RORC (0.60) | RORCSIGMAR1S1PR5S1PR1DRD2 | |
| SCHEMBL15397506 | 0.86 | RORC (0.60) | RORCSIGMAR1S1PR5S1PR1DRD2 | |
| SCHEMBL15397505 | 0.86 | RORC (0.60) | RORCSIGMAR1S1PR5S1PR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |