Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.36 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30986725 | 0.71 | TOP2A (0.46) | ARALDH1A1KDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL29044340 | 0.71 | TOP2A (0.46) | ARALDH1A1KDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL6091803 | 0.70 | KDM4E (0.41) | ALDH1A1KDM4EMAPTHPGDGAA | |
| SCHEMBL5883351 | 0.69 | KDM4E (0.41) | PDE2AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL238441 | 0.68 | CA1 (0.57) | ALDH1A1KDM4EMAPTHPGDL3MBTL1 | |
| SCHEMBL30522135 | 0.68 | POLB (0.47) | ARALDH1A1GAANPC1RAB9A | |
| SCHEMBL1284485 | 0.67 | APP (0.62) | ALDH1A1KDM4EMAPTGAAERN1 | |
| SCHEMBL13185670 | 0.67 | KDM4E (0.48) | ALDH1A1KDM4EMAPTHPGDRAB9A | |
| SCHEMBL18361190 | 0.67 | KDM4E (0.40) | PDE2AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL3059630 | 0.66 | CYP1A2 (0.47) | ALDH1A1MEN1KMT2ACTSAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010045013-A1 | PHENYL SUBSTITUTED THIENO [2,3-D] PYRIMIDINES AND THEIR USE AS ADENOSINE A2A RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-04-22 | — | — | WO | disclosed |