Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348323 | 0.77 | GRM5 (0.42) | GRM5MEN1KMT2ANPSR1OGA | |
| SCHEMBL7908663 | 0.74 | GRM5 (0.65) | GRM5CYP3A4CYP1A2MEN1KMT2A | |
| SCHEMBL30267218 | 0.74 | MEN1 (0.52) | CYP3A4MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL38653964 | 0.70 | GRM5 (0.48) | GRM5CYP3A4CYP1A2MEN1KMT2A | |
| SCHEMBL19046612 | 0.69 | GRM5 (0.58) | GRM5CYP3A4CYP1A2MEN1KMT2A | |
| SCHEMBL21078113 | 0.68 | GRM5 (0.57) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL11957019 | 0.68 | GRM5 (0.57) | GRM5CYP3A4CYP1A2MEN1KMT2A | |
| SCHEMBL11560889 | 0.68 | GRM5 (0.57) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL8315932 | 0.68 | MEN1 (0.57) | GRM5MEN1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL1967458 | 0.68 | MEN1 (0.55) | GRM5CYP3A4CYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |